{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T19:42:01Z","timestamp":1783539721441,"version":"3.55.0"},"reference-count":47,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2018,8,2]],"date-time":"2018-08-02T00:00:00Z","timestamp":1533168000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Association Fran\u00e7ois Aupetit"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Aliment Pharmacol Ther"],"published-print":{"date-parts":[[2018,10]]},"abstract":"<jats:title>Summary<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Whether healthcare workers with inflammatory bowel disease (<jats:styled-content style=\"fixed-case\">IBD<\/jats:styled-content>) are at increased risk of severe infection due to daily pathogen exposure is controversial.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aim<\/jats:title><jats:p>To assess the risk of severe infection in healthcare workers with <jats:styled-content style=\"fixed-case\">IBD<\/jats:styled-content> in a large multicentre case\u2010control study.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The study population comprised 482 healthcare workers with <jats:styled-content style=\"fixed-case\">IBD<\/jats:styled-content> from 17 centres who were matched for gender, age, disease subtype and year of diagnosis to 482 controls (non\u2010healthcare workers with IBD). The study period was between the date of diagnosis of <jats:styled-content style=\"fixed-case\">IBD<\/jats:styled-content> and June 2016. Severe infection was defined as any community\u2010acquired infection that required hospitalisation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>With a median follow\u2010up of 9.3 years, 139 severe infections were recorded among cases and controls, including 30 <jats:italic>Clostridium difficile<\/jats:italic> infections, 33 severe viral infections, nine tuberculosis infections, 21 community\u2010acquired pneumonia and 46 others. No difference was observed between healthcare workers and controls regarding the overall incidence rates of severe infection. An increased risk of tuberculosis was noted in healthcare workers. In multivariate analysis in the entire study population, severe infection was associated with current exposure to corticosteroids (<jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content> = 3.05, 95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> [2.06\u20104.52], <jats:italic>P<\/jats:italic> &lt; 0.001), immunosuppressants (<jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content> = 1.98, 95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> [1.38\u20102.84], <jats:italic>P<\/jats:italic> &lt; 0.001) and anti\u2010<jats:styled-content style=\"fixed-case\">TNF<\/jats:styled-content> agents (<jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content> = 2.93, 95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> [2.02\u20104.27], <jats:italic>P<\/jats:italic> &lt; 0.001) and reduced with Crohn's disease (<jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content> = 0.63, 95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> [0.43\u20100.91], <jats:italic>P<\/jats:italic> = 0.01).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Healthcare workers with <jats:styled-content style=\"fixed-case\">IBD<\/jats:styled-content> do not have an increased risk of severe infection compared with other patients with <jats:styled-content style=\"fixed-case\">IBD<\/jats:styled-content>, except for tuberculosis. Screening for tuberculosis exposure should be assessed in this high\u2010risk population when treated with anti\u2010<jats:styled-content style=\"fixed-case\">TNF<\/jats:styled-content> agents.<\/jats:p><\/jats:sec>","DOI":"10.1111\/apt.14926","type":"journal-article","created":{"date-parts":[[2018,8,3]],"date-time":"2018-08-03T14:11:23Z","timestamp":1533305483000},"page":"713-722","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Risk of serious infection in healthcare workers with inflammatory bowel disease: a case\u2010control study of the Groupe d'Etude Th\u00e9rapeutique des Affections Inflammatoires du tube Digestif (GETAID)"],"prefix":"10.1111","volume":"48","author":[{"given":"Charlotte","family":"Gagni\u00e8re","sequence":"first","affiliation":[{"name":"Creteil 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