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Patients and controls underwent a baseline echocardiographic evaluation including global longitudinal strain and ultrasound scan of carotid arteries. <jats:styled-content style=\"fixed-case\">HCV<\/jats:styled-content>\u2010cirrhotics were reassessed by echocardiography and carotid ultrasound after obtaining sustained virological response (<jats:styled-content style=\"fixed-case\">SVR<\/jats:styled-content>) on <jats:styled-content style=\"fixed-case\">DAA<\/jats:styled-content>s.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p><jats:styled-content style=\"fixed-case\">HCV<\/jats:styled-content>\u2010cirrhotics showed at baseline a significantly reduced global longitudinal strain compared to controls \u221218.1 (16.3\u201020.5) vs \u221221.2 (20.4\u201022.3), <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.001<jats:italic>.<\/jats:italic> They also had a significantly higher pulse wave velocity 8.6 (7.7\u20109.1) m\/s vs 6.6 (6.0\u20107.1) m\/s, <jats:italic>P<\/jats:italic>\u00a0=\u00a00.0001, and \u03b2\u2010stiffness index 12.4 (11.1\u201013.5) vs 8.6 (8.0\u20109.2) <jats:italic>P<\/jats:italic>\u00a0=\u00a00.0001. At multiple regression analysis, diabetes and <jats:styled-content style=\"fixed-case\">HCV<\/jats:styled-content> cirrhosis were independent predictors of global longitudinal strain. All <jats:styled-content style=\"fixed-case\">HCV<\/jats:styled-content>\u2010cirrhotic patients had <jats:styled-content style=\"fixed-case\">SVR<\/jats:styled-content> on <jats:styled-content style=\"fixed-case\">DAA<\/jats:styled-content>s. Follow\u2010up available in 32 of 39 (82%) at 9 (8\u201010) months showed a significant improvement of tricuspid annular plane systolic excursion (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.01<jats:italic>)<\/jats:italic> and lateral E\u2019 velocity compared to baseline (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.001).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p><jats:styled-content style=\"fixed-case\">HCV<\/jats:styled-content>\u2010cirrhotics show a significant rate of subclinical cardiac and vascular abnormalities. At a time when their survival is less linked to progression of liver disease, due to viral eradication on <jats:styled-content style=\"fixed-case\">DAA<\/jats:styled-content>s, cardiovascular morbidity and mortality may take a significant role.<\/jats:p><\/jats:sec>","DOI":"10.1111\/apt.14934","type":"journal-article","created":{"date-parts":[[2018,8,10]],"date-time":"2018-08-10T10:32:57Z","timestamp":1533897177000},"page":"740-749","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["Subclinical cardiovascular damage in patients with <scp>HCV<\/scp> cirrhosis before and after treatment with direct antiviral agents: a prospective study"],"prefix":"10.1111","volume":"48","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2127-7351","authenticated-orcid":false,"given":"Giuseppina","family":"Novo","sequence":"first","affiliation":[{"name":"Cardiology Biomedical Department of Internal Medicine and Medical Specialties 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