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Existing patient\u2010reported outcome measures (<jats:styled-content style=\"fixed-case\">PROM<\/jats:styled-content>s) evaluating quality of life in coeliac disease have not been developed in accordance with the <jats:styled-content style=\"fixed-case\">US<\/jats:styled-content> Food and Drug Administration guidelines.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aim<\/jats:title><jats:p>To develop a <jats:styled-content style=\"fixed-case\">PROM<\/jats:styled-content> in accordance with best practice guidelines, capturing all aspects of quality of life important to adults with coeliac disease.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Candidate items for the Coeliac Disease Assessment Questionnaire (<jats:styled-content style=\"fixed-case\">CDAQ<\/jats:styled-content>) were refined through item appraisal, expert review, cognitive interviews, and a translatability assessment. A cross\u2010sectional survey determined further item reduction and the <jats:styled-content style=\"fixed-case\">CDAQ<\/jats:styled-content>'s structure. The final <jats:styled-content style=\"fixed-case\">CDAQ<\/jats:styled-content> was administered alongside the Short Form Health Survey Version 2 (SF?36v2) in a second survey to assess construct validity and test\u2010retest reliability.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Pre\u2010testing the 64 candidate items revealed a range of issues which guided their refinement and reduction, resulting in the final <jats:styled-content style=\"fixed-case\">CDAQ<\/jats:styled-content> with 32 items representing 5 subscales: stigma (eight items), dietary burden (eight items), symptoms (five items), social isolation (five items), and worries and concerns (six items). Cronbach's alpha ranged between 0.82 and 0.88 for all domains. Further results showed <jats:styled-content style=\"fixed-case\">CDAQ<\/jats:styled-content> scores were more strongly correlated with the <jats:styled-content style=\"fixed-case\">SF<\/jats:styled-content>\u201036v2's mental health dimensions, as expected. Intraclass correlation coefficients ranged from 0.79 to 0.89.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The <jats:styled-content style=\"fixed-case\">CDAQ<\/jats:styled-content> is a reliable and valid coeliac\u2010specific measure that captures all aspects of quality of life important to adults with coeliac disease. Further work is underway to assess the <jats:styled-content style=\"fixed-case\">CDAQ<\/jats:styled-content>'s responsiveness to change.<\/jats:p><\/jats:sec>","DOI":"10.1111\/apt.14942","type":"journal-article","created":{"date-parts":[[2018,8,20]],"date-time":"2018-08-20T12:47:56Z","timestamp":1534769276000},"page":"852-862","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":29,"title":["Quality of life in coeliac disease: item reduction, scale development and psychometric evaluation of the Coeliac Disease Assessment Questionnaire (<scp>CDAQ<\/scp>)"],"prefix":"10.1111","volume":"48","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9786-0749","authenticated-orcid":false,"given":"Helen","family":"Crocker","sequence":"first","affiliation":[{"name":"Nuffield Department of Population Health University of Oxford Oxford UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Crispin","family":"Jenkinson","sequence":"additional","affiliation":[{"name":"Nuffield Department of Population Health University of Oxford Oxford UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0076-5981","authenticated-orcid":false,"given":"Michele","family":"Peters","sequence":"additional","affiliation":[{"name":"Nuffield Department of Population Health University of Oxford Oxford UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,8,20]]},"reference":[{"key":"e_1_2_8_2_1","first-page":"1037","volume":"55","author":"Heel DA","year":"2006","journal-title":"Recent advances in coeliac disease. 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