{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T23:31:08Z","timestamp":1792452668082,"version":"4.5.0"},"reference-count":54,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2018,8,24]],"date-time":"2018-08-24T00:00:00Z","timestamp":1535068800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100002915","name":"Fondation pour la Recherche M\u00e9dicale","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002915","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001677","name":"Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001677","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Aliment Pharmacol Ther"],"published-print":{"date-parts":[[2018,11]]},"abstract":"Summary<\/jats:title>\n \n Background<\/jats:title>\n Intestinal microbiota plays an important role in bile acid homeostasis.<\/jats:p>\n <\/jats:sec>\n \n Aim<\/jats:title>\n To study the structure of the intestinal microbiota and its function in bile acid homeostasis in alcoholic patients based on the severity of alcoholic liver disease.<\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n \n In this prospective study, we included four groups of active alcoholic patients (N\u00a0=\u00a0108): two noncirrhotic, with (noCir_\n AH<\/jats:styled-content>\n , n\u00a0=\u00a013) or without alcoholic hepatitis (noCir_no\n AH<\/jats:styled-content>\n , n\u00a0=\u00a061), and two cirrhotic, with (Cir_\n sAH<\/jats:styled-content>\n , n\u00a0=\u00a017) or without severe alcoholic hepatitis (Cir_no\n AH<\/jats:styled-content>\n , n\u00a0=\u00a017). Plasma and faecal bile acid profiles and intestinal microbiota composition were assessed.\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n Plasma levels of total bile acids (84.6 vs 6.8\u00a0\u03bcmol\/L,\n P<\/jats:italic>\n \u00a0<\u00a00.001) and total ursodeoxycholic acid (1.3 vs 0.3\u00a0\u03bcmol\/L,\n P<\/jats:italic>\n \u00a0=\u00a00.03) were higher in cirrhosis with severe alcoholic hepatitis (Cir_\n sAH<\/jats:styled-content>\n ) than Cir_no\n AH<\/jats:styled-content>\n , whereas total faecal (2.4 vs 11.3,\n P<\/jats:italic>\n \u00a0=\u00a00.01) and secondary bile acids (0.7 vs 10.7,\n P<\/jats:italic>\n \u00a0<\u00a00.01) levels were lower. Cir_\n sAH<\/jats:styled-content>\n patients had a different microbiota than Cir_no\n AH<\/jats:styled-content>\n patients: at the phyla level, the abundance of Actinobacteria (9 vs 1%,\n P<\/jats:italic>\n \u00a0=\u00a00.01) was higher and that of Bacteroidetes was lower (25 vs 40%,\n P<\/jats:italic>\n \u00a0=\u00a00.04). Moreover, the microbiota of Cir_\n sAH<\/jats:styled-content>\n patients showed changes in the abundance of genes involved in 15 metabolic pathways, including upregulation of glutathione metabolism, and downregulation of biotin metabolism.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n \n Patients with Cir_\n sAH<\/jats:styled-content>\n show specific changes of the bile acid pool with a shift towards more hydrophobic and toxic species that may be responsible for the specific microbiota changes. Conversely, the microbiota may also alter the bile acid pool by transforming primary to secondary bile acids, leading to a vicious cycle.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/apt.14949","type":"journal-article","created":{"date-parts":[[2018,8,24]],"date-time":"2018-08-24T04:26:38Z","timestamp":1535084798000},"page":"961-974","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":109,"title":["Bile acid homeostasis and intestinal dysbiosis in alcoholic hepatitis"],"prefix":"10.1111","volume":"48","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0416-1584","authenticated-orcid":false,"given":"Dragos","family":"Ciocan","sequence":"first","affiliation":[{"name":"Inflammation Chimiokines et Immunopathologie DHU Hepatinov Facult\u00e9 de M\u00e9decine\u2010Universit\u00e9 Paris\u2010Sud\/Universit\u00e9 Paris\u2010Saclay INSERM UMR\u2010S 996 Clamart 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