{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,27]],"date-time":"2025-07-27T07:53:35Z","timestamp":1753602815444,"version":"3.37.3"},"reference-count":36,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2018,10,30]],"date-time":"2018-10-30T00:00:00Z","timestamp":1540857600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Aliment Pharmacol Ther"],"published-print":{"date-parts":[[2018,11]]},"abstract":"<jats:title>Summary<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Hepatitis C virus (HCV) infection is associated with production of different serum non\u2010organ\u2010specific antibodies (NOSA) and risk for developing autoimmune disorders. The clinical significance of these phenomena is not fully understood.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aim<\/jats:title><jats:p>To assess non\u2010organ\u2010specific antibodies before and 24\u00a0weeks after the end of therapy with direct\u2010acting antivirals in patients with HCV\u2010related infection, to better clarify the clinical relevance of these antibodies in terms of treatment response and prognostic value.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Patients enrolled (191) were considered non\u2010organ\u2010specific antibody\u2010positive for titres \u22651:40 on at least two determinations before treatment.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>At baseline, 46 patients were positive and 145 were negative for autoantibodies. The prevalence of autoimmune thyroiditis was significantly higher in non\u2010organ\u2010specific antibody\u2010positive group than non\u2010organ\u2010specific antibody\u2010negative group (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.02). HCV\u2010RNA 24\u00a0weeks after the end of antiviral therapy was 100% negative in patients with antibodies positivity and 98.6% in antibody\u2010negative patients (<jats:italic>P<\/jats:italic>\u00a0=\u00a01.0). In the former group, autoantibodies disappeared in 30 of 46 patients (65.2%). On multivariate analysis, non\u2010organ\u2010specific antibody\u2010negativity was significantly reduced in patients with hepatic hilar lymphadenopathy (OR\u00a0=\u00a00.17; 95% CI 0.02\u20100.94, <jats:italic>P<\/jats:italic>\u00a0=\u00a00.04). None of the adverse events occurring during antiviral therapy was related to autoimmune disorders.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Hepatitis C virus clearance frequently reduces non\u2010organ\u2010specific antibody positivity suggesting that they represent an epiphenomenon of the viral infection. However, in patients who did not become negative, long\u2010term monitoring would establish whether they could hide an underlying process that may progress into a clear autoimmune or rheumatologic disease. (Trial registration number: NCT03566966).<\/jats:p><\/jats:sec>","DOI":"10.1111\/apt.14999","type":"journal-article","created":{"date-parts":[[2018,10,30]],"date-time":"2018-10-30T14:07:33Z","timestamp":1540908453000},"page":"1138-1145","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Clinical relevance of serum non\u2010organ\u2010specific antibodies in patients with HCV infection receiving direct\u2010acting antiviral therapy"],"prefix":"10.1111","volume":"48","author":[{"given":"Endrit","family":"Shahini","sequence":"first","affiliation":[{"name":"Gastroenterology Unit, Department of Emergency and Organ Transplantation (D.E.T.O.) 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