{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,26]],"date-time":"2026-10-26T12:06:12Z","timestamp":1793016372661,"version":"4.5.0"},"reference-count":29,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2018,10,30]],"date-time":"2018-10-30T00:00:00Z","timestamp":1540857600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001711","name":"Schweizerischer Nationalfonds zur F\u00f6rderung der Wissenschaftlichen Forschung","doi-asserted-by":"publisher","award":["32003B_135665 and 32473B_160115"],"award-info":[{"award-number":["32003B_135665 and 32473B_160115"]}],"id":[{"id":"10.13039\/501100001711","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Aliment Pharmacol Ther"],"published-print":{"date-parts":[[2018,11]]},"abstract":"<jats:title>Summary<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Well informed patients who are in cohesive partnership with physicians and who have realistic expectations towards therapy are more likely to be adherent, which results in better disease control.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aim<\/jats:title><jats:p>To assess which therapy goals adults with eosinophilic oesophagitis consider relevant.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Following refinement during three focus groups, a study brochure and questionnaire were sent to 148 patients. Patients ranked the importance (five levels) of short\u2010term (in the next 3\u00a0months) and long\u2010term (\u22651\u00a0year) treatment effect on symptoms, quality of life (QoL), histologically\u2010detected inflammation and fibrosis, endoscopically\u2010detected inflammation, and stricture formation as well as achieving histological remission while asymptomatic. Patients\u2019 characteristics associated with treatment goals were identified using logistic regression.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Of 109 respondents (mean age 43\u00a0years), 85 were men. Over 90% chose symptoms and QoL improvement as important short\u2010 and long\u2010term therapy goals. A greater proportion attributed more importance to long\u2010term reduction in endoscopic (90% vs 73%, <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.001) and histological (81% vs 62%, <jats:italic>P<\/jats:italic>\u00a0=\u00a00.002) inflammation, and histologically\u2010detected fibrosis (79% vs 64%, <jats:italic>P<\/jats:italic>\u00a0=\u00a00.018) when compared to short\u2010term reduction in these features. Patients (88%) ranked achieving histological remission while being asymptomatic as important. Gender, therapy use, education level, QoL, symptom severity, and history of dilation were associated with patients\u2019 choice of treatment goals.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Patients attributed most importance to improvement in symptoms and QoL. Reduction in biological activity was judged less important, but more relevant in the long\u2010 compared to the short\u2010term.<\/jats:p><\/jats:sec>","DOI":"10.1111\/apt.15000","type":"journal-article","created":{"date-parts":[[2018,10,30]],"date-time":"2018-10-30T14:07:33Z","timestamp":1540908453000},"page":"1082-1090","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":33,"title":["Adults with eosinophilic oesophagitis identify symptoms and quality of life as the most important outcomes"],"prefix":"10.1111","volume":"48","author":[{"given":"Ekaterina","family":"Safroneeva","sequence":"first","affiliation":[{"name":"Institute of Social and Preventive Medicine University of Bern Bern Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lukas","family":"Balsiger","sequence":"additional","affiliation":[{"name":"Division of Internal Medicine Kantonsspital Langenthal Solothurn Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Hafner","sequence":"additional","affiliation":[{"name":"Institute of Social and Preventive Medicine University of Bern Bern Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudia E.","family":"Kuehni","sequence":"additional","affiliation":[{"name":"Institute of Social and Preventive Medicine University of Bern Bern Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcel","family":"Zwahlen","sequence":"additional","affiliation":[{"name":"Institute of Social and Preventive Medicine University of Bern Bern Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sven","family":"Trelle","sequence":"additional","affiliation":[{"name":"Institute of Social and Preventive Medicine Clinical Trials Unit Bern University of Bern Bern Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S\u00e9bastien","family":"Godat","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Hepatology Centre Hospitalier Universitaire Vaudois (CHUV) Lausanne Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luc","family":"Biedermann","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Hepatology University Hospital Zurich Zurich Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Greuter","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Hepatology University Hospital Zurich Zurich Switzerland"},{"name":"Division of Gastroenterology Mayo Clinic Rochester Minnesota"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephan","family":"Vavricka","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Hepatology University Hospital Zurich Zurich Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alex","family":"Straumann","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Hepatology University Hospital Zurich Zurich Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6341-9536","authenticated-orcid":false,"given":"Alain M.","family":"Schoepfer","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Hepatology Centre Hospitalier Universitaire Vaudois (CHUV) Lausanne Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,10,30]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2011.02.040"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra1502863"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1177\/2050640616689525"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2012.03.005"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2007.10.002"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2013.08.015"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2008.02.003"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/dote.12391"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/all.12455"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2015.11.004"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.giec.2017.08.001"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1097\/MLR.0b013e31819a5acc"},{"key":"e_1_2_7_14_1","unstructured":"ApterAJ BochnerBS HollingsworthH.Enhancing patient adherence to asthma therapy.2007. 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