{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,13]],"date-time":"2026-01-13T21:11:14Z","timestamp":1768338674476,"version":"3.49.0"},"reference-count":38,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2018,10,8]],"date-time":"2018-10-08T00:00:00Z","timestamp":1538956800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100003522","name":"Crohn's and Colitis UK","doi-asserted-by":"publisher","award":["M10\u20101"],"award-info":[{"award-number":["M10\u20101"]}],"id":[{"id":"10.13039\/501100003522","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Aliment Pharmacol Ther"],"published-print":{"date-parts":[[2018,11]]},"abstract":"<jats:title>Summary<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Inflammatory bowel disease (<jats:styled-content style=\"fixed-case\">IBD<\/jats:styled-content>) increases the risk of venous thromboembolism.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aims<\/jats:title><jats:p>To determine when patients are at high risk of thromboembolic events, including after major surgery, and to guide timing of thromboprophylaxis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Each IBD patient from Clinical Practice Research Datalink, linked with Hospital Episode Statistics, was matched to up to five non\u2010<jats:styled-content style=\"fixed-case\">IBD<\/jats:styled-content> patients in this cohort study. We examined their risk of thromboembolism in hospital and within 6\u00a0weeks after leaving hospital, with or without undergoing major surgery, and while ambulant. Hazard ratios were estimated using Cox regression, with adjustment for age, sex, body mass index, smoking and history of malignancy or thromboembolism.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Overall 23\u00a0046 IBD patients had a thromboembolic risk 1.74\u2010times (95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>\u00a0=\u00a01.55\u20101.96) higher than 106\u00a0795 non\u2010<jats:styled-content style=\"fixed-case\">IBD<\/jats:styled-content> patients. Among ambulant patients, the thromboembolic risk was raised during acute (hazard ratio\u00a0=\u00a03.94, 2.79\u20105.57) or chronic disease activity (3.97, 2.90\u20105.45) but their absolute risk remained below 5\/1000 person\u2010years. The hazard ratio for thromboembolism among in\u2010patients not undergoing major surgery was 1.13 (0.63\u20102.02), compared to 2.43 (1.20\u20104.92) among surgical patients, with a near doubling of absolute risk associated with surgery (59.5\/1000 person\u2010years, compared with 31.1 without surgery). The absolute risk remained elevated within 6\u00a0weeks after leaving hospital (18.6\/1000 person\u2010years in IBD patients after surgery).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>IBD patients are at an increased risk of venous thromboembolism. Absolute risks are raised during active disease, when in hospital, and after leaving hospital following major surgery.<\/jats:p><\/jats:sec>","DOI":"10.1111\/apt.15010","type":"journal-article","created":{"date-parts":[[2018,10,8]],"date-time":"2018-10-08T07:14:07Z","timestamp":1538982847000},"page":"1099-1108","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":47,"title":["The risk of venous thromboembolism during and after hospitalisation in patients with inflammatory bowel disease activity"],"prefix":"10.1111","volume":"48","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5482-7674","authenticated-orcid":false,"given":"Thomas P. 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