{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,11]],"date-time":"2026-08-11T02:52:01Z","timestamp":1786416721354,"version":"build-2736575974"},"reference-count":25,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2018,11,15]],"date-time":"2018-11-15T00:00:00Z","timestamp":1542240000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81270506"],"award-info":[{"award-number":["81270506"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81570555"],"award-info":[{"award-number":["81570555"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003397","name":"Huazhong University of Science and Technology","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003397","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Aliment Pharmacol Ther"],"published-print":{"date-parts":[[2019,1]]},"abstract":"<jats:title>Summary<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The diagnostic value of ascitic cholesterol in the differential diagnosis of ascites is controversial.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aim<\/jats:title><jats:p>To investigate the diagnostic performance of ascitic cholesterol in the differential diagnosis of ascites.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Consecutive patients with new\u2010onset ascites were enrolled prospectively. The pertinent data were collected from 629 patients with all forms of ascites.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In the training cohort, determination of the ascitic cholesterol level was a highly effective method of distinguishing non\u2010portal hypertension (NPH) from portal hypertension (PH). At the pre\u2010determined cut\u2010off value of 45\u00a0mg\/dL, the sensitivity of ascitic cholesterol was superior to the serum\u2010ascites albumin gradient (SAAG) in identifying NPH\u2010related ascites; the area under the receiver operating characteristic curve was 0.945. In the patients misdiagnosed based on SAAG classification, the diagnostic accuracy of ascitic cholesterol was 69%. The ascitic cholesterol level showed excellent performance in identifying peritoneal lesions in patients with mixed ascites.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Ascitic cholesterol is an excellent measure for detecting NPH ascites and for identifying peritoneal lesions in mixed ascites. Thus, this simple and cost\u2010effective measure should be determined in patients with new\u2010onset ascites (<jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"www.chictr.org.cn\">www.chictr.org.cn<\/jats:ext-link>; ChiCTR\u2010DCD\u201015006907).<\/jats:p><\/jats:sec>","DOI":"10.1111\/apt.15042","type":"journal-article","created":{"date-parts":[[2018,11,16]],"date-time":"2018-11-16T04:55:52Z","timestamp":1542344152000},"page":"91-98","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":25,"title":["Ascitic cholesterol is superior to serum\u2010ascites albumin gradient in the detection of non\u2010portal hypertensive ascites and the diagnosis of mixed ascites"],"prefix":"10.1111","volume":"49","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8864-6380","authenticated-orcid":false,"given":"Li","family":"Du","sequence":"first","affiliation":[{"name":"Division of Gastroenterology Union Hospital, Tongji 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