{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T12:59:23Z","timestamp":1792501163900,"version":"4.5.0"},"reference-count":47,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2018,12,27]],"date-time":"2018-12-27T00:00:00Z","timestamp":1545868800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100005845","name":"Hyogo College of Medicine","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100005845","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Aliment Pharmacol Ther"],"published-print":{"date-parts":[[2019,1]]},"abstract":"<jats:title>Summary<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Proton pump inhibitors (PPIs) are widely used to treat gastro\u2010oesophageal reflux disease (GORD). However, the onset of action is considered slow and PPIs cannot completely block acid secretion at night. A new potassium\u2010competitive acid blocker (P\u2010CAB) can rapidly block acid secretion. However, whether this P\u2010CAB can relieve GORD symptoms quickly and adequately soon after starting treatment is unknown.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aim<\/jats:title><jats:p>To determine how rapidly vonoprazan and lansoprazole provide heartburn relief.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Patients (n\u00a0=\u00a032) with endoscopically confirmed erosive oesophagitis who experienced heartburn at least once a week were randomised in a double\u2010blind manner to receive either daily vonoprazan (20\u00a0mg) or lansoprazole (30\u00a0mg) before breakfast for 14\u00a0days. Day time and night time heartburn were assessed daily throughout the study using a five\u2010point Likert scale. The primary endpoint was the first day of complete day and night heartburn relief for at least seven consecutive days. The ethics committees of the participating institutions approved the study protocol.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Heartburn was relieved sooner with vonoprazan than with lansoprazole (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.05, log\u2010rank test). Heartburn was completely relieved in 31.3% and 12.5% of patients on day 1 with vonoprazan and lansoprazole, respectively. Significantly more patients achieved complete nocturnal heartburn relief with vonoprazan than lansoprazole (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.01). Both regimens were well tolerated.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Complete sustained heartburn relief was achieved sooner with vonoprazan than with lansoprazole during the first week of therapy. 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