{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T14:20:31Z","timestamp":1788877231618,"version":"build-2803163510"},"reference-count":46,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2018,12,27]],"date-time":"2018-12-27T00:00:00Z","timestamp":1545868800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100002341","name":"Academy of Finland","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002341","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004212","name":"P\u00e4ivikki ja Sakari Sohlbergin S\u00e4\u00e4ti\u00f6","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004212","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010600","name":"Tays","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100010600","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100008723","name":"Suomen L\u00e4\u00e4ketieteen S\u00e4\u00e4ti\u00f6","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008723","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Aliment Pharmacol Ther"],"published-print":{"date-parts":[[2019,2]]},"abstract":"<jats:title>Summary<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The revised paediatric criteria for coeliac disease allow omission of duodenal biopsies in symptomatic children who have specific serology and coeliac disease\u2010associated genetics. It remains unclear whether this approach is also applicable for adults with various clinical presentations.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aim<\/jats:title><jats:p>To evaluate the accuracy of serology\u2010based criteria in adults with variable pre\u2010test probabilities for coeliac disease.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Three study cohorts comprised adults with high\u2010risk clinical coeliac disease suspicion (n\u00a0=\u00a0421), moderate\u2010risk family members of coeliac disease patients (n\u00a0=\u00a02357), and low\u2010risk subjects from the general population (n\u00a0=\u00a02722). Serological and clinical data were collected, and \u201ctriple criteria\u201d for coeliac disease comprised transglutaminase 2 antibodies &gt;10\u00d7 the upper limit of normal, positive endomysium antibodies, and appropriate genetics without requirement of symptoms. The diagnosis was based on intestinal biopsy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The diagnosis of coeliac disease was established in 274 subjects. Of these, 59 high\u2010risk subjects, 17 moderate\u2010risk subjects, and 14 low\u2010risk subjects fulfilled the \u201ctriple criteria\u201d. All had histologically proven coeliac disease, giving the criteria a positive predictive value of 100%. Altogether, 90 (33%) of all 274 newly diagnosed patients could have avoided biopsy, including 37% among high\u2010risk, 20% among moderate\u2010risk, and 48% among low\u2010risk patients. No histological findings other than coeliac disease were found in the biopsies of \u201ctriple positive\u201d subjects.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Coeliac disease can reliably and safely be diagnosed without biopsy in adults fulfilling the \u201ctriple criteria\u201d regardless of the pre\u2010test probability. Revised criteria would enable the number of endoscopies to be reduced by one\u2010third.<\/jats:p><\/jats:sec>","DOI":"10.1111\/apt.15109","type":"journal-article","created":{"date-parts":[[2018,12,28]],"date-time":"2018-12-28T02:34:59Z","timestamp":1545964499000},"page":"277-284","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":87,"title":["Serology\u2010based criteria for adult coeliac disease have excellent accuracy across the range of pre\u2010test probabilities"],"prefix":"10.1111","volume":"49","author":[{"given":"Valma","family":"Fuchs","sequence":"first","affiliation":[{"name":"Celiac Disease Research Center Faculty of Medicine and Life Sciences University of Tampere  Tampere Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4757-2164","authenticated-orcid":false,"given":"Kalle","family":"Kurppa","sequence":"additional","affiliation":[{"name":"Tampere Center for 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