{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T03:18:02Z","timestamp":1788837482494,"version":"build-2803163510"},"reference-count":37,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2019,1,13]],"date-time":"2019-01-13T00:00:00Z","timestamp":1547337600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100004587","name":"Instituto de Salud Carlos III","doi-asserted-by":"publisher","award":["PI13\/00041"],"award-info":[{"award-number":["PI13\/00041"]}],"id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Aliment Pharmacol Ther"],"published-print":{"date-parts":[[2019,2]]},"abstract":"Summary<\/jats:title>\n \n Background<\/jats:title>\n \n Cohort studies comparing the characteristics of childhood\u2010onset and adulthood\u2010onset inflammatory bowel disease (\n IBD<\/jats:styled-content>\n ) in the biologics era are scarce.\n <\/jats:p>\n <\/jats:sec>\n \n Aim<\/jats:title>\n \n To compare disease characteristics, the use of immunomodulators and biologic agents and the need for surgery between childhood\u2010 and adulthood\u2010onset\n IBD<\/jats:styled-content>\n .\n <\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n \n Inflammatory bowel disease patients from the\n ENEIDA<\/jats:styled-content>\n registry diagnosed between 2007 and 2017 were included. The childhood\u2010onset cohort comprised patients diagnosed at \u226416\u00a0years of age and the adulthood\u2010onset cohort those diagnosed at >16\u00a0years. The cumulative incidences of immunosuppressive therapy, biologic therapy and surgery were estimated using Kaplan\u2010Meier curves, compared by the log\u2010rank test. Cox regression analysis was performed to identify potential predictive factors of treatment with immunosuppressants, biologic agents or surgery.\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n The adulthood\u2010onset cohort comprised 21\u00a0200 patients out of 20\u00a0354 (96%) and the childhood\u2010onset cohort 846 (4%). Median follow\u2010up was 54\u00a0months in the childhood\u2010onset cohort and 38\u00a0months in the adulthood\u2010onset cohort (\n P<\/jats:italic>\n \u00a0<\u00a00.01). Proportions of Crohn's disease, ileocolonic involvement and inflammatory behaviour at diagnosis were higher in the childhood\u2010onset cohort. In the multivariate analysis, after adjusting for sex, type of\n IBD<\/jats:styled-content>\n , extraintestinal manifestations, family history and smoking habit, childhood\u2010onset IBD was associated with higher risk of immunomodulator use (hazard ratio [\n HR<\/jats:styled-content>\n ]\u00a0=\u00a01.2, 95% confidence interval [95%\n CI<\/jats:styled-content>\n ]\u00a0=\u00a01.1\u20101.2) and higher probability of receiving biologic treatment (\n HR<\/jats:styled-content>\n \u00a0=\u00a01.2, 95%\n CI<\/jats:styled-content>\n \u00a0=\u00a01.1\u20101.3). However, childhood\u2010onset IBD was not associated with higher risk of surgery (\n HR<\/jats:styled-content>\n \u00a0=\u00a00.9, 95%\n CI<\/jats:styled-content>\n \u00a0=\u00a00.8\u20101.2).\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n \n Childhood\u2010onset\n IBD<\/jats:styled-content>\n has differential characteristics and higher risk of treatment with immunomodulators and biologic agents, compared with adulthood\u2010onset\n IBD<\/jats:styled-content>\n . Nevertheless, paediatric\n IBD<\/jats:styled-content>\n is not associated with higher risk of surgery.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/apt.15114","type":"journal-article","created":{"date-parts":[[2019,1,13]],"date-time":"2019-01-13T23:29:31Z","timestamp":1547422171000},"page":"419-428","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":46,"title":["Differences between childhood\u2010 and adulthood\u2010onset inflammatory bowel disease: the\n CAROUSEL<\/scp>\n study from\n GETECCU<\/scp>"],"prefix":"10.1111","volume":"49","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9275-4242","authenticated-orcid":false,"given":"Mar\u00eda","family":"Chaparro","sequence":"first","affiliation":[{"name":"Gastroenterology Unit Instituto de Investigaci\u00f3n Sanitaria Princesa (IIS\u2010IP) and CIBERehd Hospital Universitario de La Princesa Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana","family":"Garre","sequence":"additional","affiliation":[{"name":"Gastroenterology Unit Instituto de Investigaci\u00f3n Sanitaria Princesa (IIS\u2010IP) and CIBERehd Hospital Universitario de La Princesa Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elena","family":"Ricart","sequence":"additional","affiliation":[{"name":"Gastroenterology Unit and CIBERehd Hospital Clinic de Barcelona Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eva","family":"Iglesias\u2010Flores","sequence":"additional","affiliation":[{"name":"Gastroenterology Unit and IMIBIC Hospital Reina Sof\u00eda C\u00f3rdoba Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlos","family":"Taxonera","sequence":"additional","affiliation":[{"name":"Gastroenterology Unit Hospital Cl\u00ednico San Carlos Madrid 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