{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,9]],"date-time":"2026-11-09T21:00:39Z","timestamp":1794258039650,"version":"4.9.0"},"reference-count":56,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2019,1,9]],"date-time":"2019-01-09T00:00:00Z","timestamp":1546992000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Aliment Pharmacol Ther"],"published-print":{"date-parts":[[2019,2]]},"abstract":"Summary<\/jats:title>Background<\/jats:title>Faecal microbiota transplantation (FMT<\/jats:styled-content>) is effective for Clostridium difficile<\/jats:italic> infections (CDI<\/jats:styled-content>) refractory to standard treatment and is being studied in other diseases.<\/jats:p><\/jats:sec>Aim<\/jats:title>To evaluate donor characteristics, procedures and clinical outcomes of FMT<\/jats:styled-content>.<\/jats:p><\/jats:sec>Methods<\/jats:title>We systematically reviewed FMT<\/jats:styled-content> studies published up to 29 August 2018 using MEDLINE<\/jats:styled-content> (R) and EMBASE<\/jats:styled-content> and identified clinical studies with FMT<\/jats:styled-content> donor information. We reported data on donor characteristics, screening criteria, administration, clinical outcomes and adverse events.<\/jats:p><\/jats:sec>Results<\/jats:title>Among 5267 reports, 239 full\u2010text articles were screened and 168 articles were included. FMT<\/jats:styled-content> was performed commonly for CDI<\/jats:styled-content> (n\u00a0=\u00a0108) and inflammatory bowel disease (IBD<\/jats:styled-content>) (n\u00a0=\u00a031). We reported characteristics of 1513 donors [58% male; mean age, 34.3\u00a0years; mean body mass index, 21.6]. Donors in Asia were younger than the West (mean age 30.7 vs 32.9, P<\/jats:italic>\u00a0=\u00a00.00075). Less than 50% of studies screened donors for transmittable pathogens. Final cure rate for CDI<\/jats:styled-content> was 95.6% (95% confidence interval [CI<\/jats:styled-content>], 93.9%\u201097.1%) and final remission rates for ulcerative colitis (UC<\/jats:styled-content>) and Crohn's disease (CD<\/jats:styled-content>) were 39.6% (95% CI<\/jats:styled-content>, 25.4%\u201054.6%) and 47.5% (95% CI<\/jats:styled-content>, 29.4%\u201065.8%), respectively. Cure rates in CDI<\/jats:styled-content> and final remission rates for CD<\/jats:styled-content> and UC<\/jats:styled-content> were comparable across all routes of FMT<\/jats:styled-content> administration. Overall adverse event incidence was <1%, mostly GI<\/jats:styled-content>\u2010related. Adverse event rates did not differ significantly between routes of FMT<\/jats:styled-content> administration or indication.<\/jats:p><\/jats:sec>Conclusions<\/jats:title>In a systematic review assessing donor characteristics and FMT<\/jats:styled-content> efficacy, we observed heterogeneity in donor selection, application and outcomes of FMT<\/jats:styled-content>. These data can facilitate standardisation of FMT<\/jats:styled-content> protocols for various diseases.<\/jats:p><\/jats:sec>","DOI":"10.1111\/apt.15116","type":"journal-article","created":{"date-parts":[[2019,1,10]],"date-time":"2019-01-10T06:25:51Z","timestamp":1547101551000},"page":"354-363","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":106,"title":["Systematic review with meta\u2010analysis: review of donor features, procedures and outcomes in 168 clinical studies of faecal microbiota transplantation"],"prefix":"10.1111","volume":"49","author":[{"given":"Cheuk Yin","family":"Lai","sequence":"first","affiliation":[{"name":"Department of Medicine and Therapeutics The Chinese University of Hong Kong Hong Kong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joanne","family":"Sung","sequence":"additional","affiliation":[{"name":"Department of Medicine and Therapeutics The Chinese University of Hong Kong 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