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Only articles with patients from East Asian countries were included.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>After review, 34 articles were selected (Japan\u00a0=\u00a09; China\u00a0=\u00a05, Korea\u00a0=\u00a03, Taiwan\u00a0=\u00a016, multiple countries\u00a0=\u00a01) with 646\u00a0228 subjects, 66\u00a0436 with<jats:styled-content style=\"fixed-case\">HCV<\/jats:styled-content>. Mean age for<jats:styled-content style=\"fixed-case\">HCV<\/jats:styled-content>\u2010infected patients was 56\u00a0years (range 41\u201072\u00a0years), 50% were male (range 26%\u201073%). The pooled prevalence of type 2 diabetes in East Asian<jats:styled-content style=\"fixed-case\">HCV<\/jats:styled-content>patients was 19.0% (95% confidence interval 15.6%\u201022.9%) (n\u00a0=\u00a019 studies) with an increased risk when compared to non\u2010<jats:styled-content style=\"fixed-case\">HCV<\/jats:styled-content>: odds ratio (<jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content>) 1.58 (1.28\u20101.94). The prevalence of chronic kidney disease in<jats:styled-content style=\"fixed-case\">HCV<\/jats:styled-content>was 9.2% (5.0%\u201016.2%) (n\u00a0=\u00a07 studies), also with a significantly increased risk:<jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content>=1.98 (1.41\u20102.77). Pooled prevalence of cardiovascular disease in<jats:styled-content style=\"fixed-case\">HCV<\/jats:styled-content>was 8.6% (3.5%\u201019.9%) (n\u00a0=\u00a06 studies), also with an increased risk:<jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content>\u00a0=\u00a01.55 (1.21\u20101.98). The prevalence of lichen planus in<jats:styled-content style=\"fixed-case\">HCV<\/jats:styled-content>was 8.9% (3.6%\u201020.6%) (n\u00a0=\u00a06 studies) while the prevalence of rheumatoid arthritis was 4.5% (0.6%\u201025.7%) (n\u00a0=\u00a04 studies).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>These data show increased risk of developing extrahepatic manifestations in East Asian patients with<jats:styled-content style=\"fixed-case\">HCV<\/jats:styled-content>. Both hepatic and extrahepatic manifestations of the infection should be used to accurately determine the total burden of the disease in the region.<\/jats:p><\/jats:sec>","DOI":"10.1111\/apt.15131","type":"journal-article","created":{"date-parts":[[2019,2,14]],"date-time":"2019-02-14T07:55:16Z","timestamp":1550130916000},"page":"644-653","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":33,"title":["Systematic review with meta\u2010analysis: extrahepatic manifestations in chronic hepatitis C virus\u2010infected patients in East Asia"],"prefix":"10.1111","volume":"49","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9313-577X","authenticated-orcid":false,"given":"Zobair M.","family":"Younossi","sequence":"first","affiliation":[{"name":"Falls Church Virginia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Linda","family":"Henry","sequence":"additional","affiliation":[{"name":"Falls Church Virginia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Janus","family":"P. 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