{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T16:02:47Z","timestamp":1792598567786,"version":"4.5.0"},"reference-count":35,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2019,1,27]],"date-time":"2019-01-27T00:00:00Z","timestamp":1548547200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Aliment Pharmacol Ther"],"published-print":{"date-parts":[[2019,3]]},"abstract":"<jats:title>Summary<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Primary sclerosing cholangitis is associated with an increased risk of biliary tract cancer. Carbohydrate antigen 19\u20109 (CA19\u20109) can be used to screen for these malignancies.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>To perform a longitudinal analysis of CA19\u20109 in patients with primary sclerosing cholangitis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We conducted a retrospective analysis of CA19\u20109 values in patients who had primary sclerosing cholangitis, with and without biliary malignancy. We calculated the index of individuality and reference change value in patients who were cancer\u2010free. Long\u2010term analysis of CA19\u20109 in cancer\u2010free patients was performed and we assessed the change of CA19\u20109 prior to diagnosis of cancer.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      We obtained 1818 CA19\u20109 values from 247 patients, including 32 with malignancy. Median CA19\u20109 in cancer\u2010free individuals was 15.6\u00a0U\/mL. The index of individuality was 0.37 and the reference change value was 46.23%. In cancer\u2010free patients, no significant change in CA19\u20109 was observed at 1, 2, 5, 7, 10, 15, and 20\u00a0years after initial diagnosis of primary sclerosing cholangitis. In patients with biliary tract cancer, CA19\u20109 was higher at 3\u00a0months prior to diagnosis (\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0&lt;\u00a00.05) than at 6\u00a0months before diagnosis and was also higher than at 3\u00a0months prior to last follow\u2010up in cancer\u2010free patients (\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0&lt;\u00a00.05). In 92.9% of patients with biliary cancer, we found an increase in CA19\u20109 of &gt;46.23% in the year prior to cancer diagnosis.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>CA19\u20109 in patients with primary sclerosing cholangitis is highly individual, and the reference change value should be preferred to reference intervals. In this study, CA19\u20109 remained stable in patients who were cancer\u2010free but increased early in those who developed biliary tract cancer. Regular CA19\u20109 measurement might improve early detection of these malignancies.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/apt.15146","type":"journal-article","created":{"date-parts":[[2019,1,28]],"date-time":"2019-01-28T02:24:57Z","timestamp":1548642297000},"page":"769-778","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Longitudinal analysis of CA19\u20109 reveals individualised normal range and early changes before development of biliary tract cancer in patients with primary sclerosing cholangitis"],"prefix":"10.1111","volume":"49","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9660-1323","authenticated-orcid":false,"given":"Andreas","family":"Wannhoff","sequence":"first","affiliation":[{"name":"Department of Internal Medicine IV University Hospital Heidelberg Heidelberg 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