{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T06:50:26Z","timestamp":1792651826439,"version":"4.5.0"},"reference-count":45,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2019,2,10]],"date-time":"2019-02-10T00:00:00Z","timestamp":1549756800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Aliment Pharmacol Ther"],"published-print":{"date-parts":[[2019,3]]},"abstract":"<jats:title>Summary<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>After liver transplantation primary sclerosing cholangitis (PSC), the condition returns in the transplanted liver in a subset of patients (recurrent primary sclerosing cholangitis, rPSC).<\/jats:p><\/jats:sec><jats:sec><jats:title>Aim<\/jats:title><jats:p>To define risk factors for rPSC.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We searched Pubmed, Embase, Web of Science, and Cochrane library for articles published until March 2018. Studies addressing risk factors for developing rPSC were eligible for inclusion. A random effects meta\u2010analysis was conducted using hazard ratios (HR) as effect measure. Study quality was evaluated with the Newcastle Ottawa scale. Statistical analysis was performed using Cochrane Review Manager.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The electronic database search yielded 449 results. Twenty\u2010one retrospective cohort studies met the inclusion criteria for the review; 14 were included in the meta\u2010analysis. The final cohort included 2159 patients (age range 31\u201049 years, 68.8% male), of whom 17.7% developed rPSC. Colectomy before liver transplantation, HR 0.65 (95% CI: 0.42\u20100.99), cholangiocarcinoma before liver transplantation, HR 2.42 (95% CI: 1.20\u20104.86), inflammatory bowel disease, HR 1.73 (95% CI: 1.17\u20102.54), donor age, HR 1.24 (95% CI 1.0\u20101.45) per ten years, MELD score, HR 1.05 (95% CI: 1.02\u20101.08) per point and acute cellular rejection, HR of 1.94 (95% CI: 1.32\u20102.83) were associated with the risk of rPSC.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Multiple risk factors for rPSC were identified. Colectomy before liver transplantation reduced the risk of rPSC.<\/jats:p><\/jats:sec>","DOI":"10.1111\/apt.15148","type":"journal-article","created":{"date-parts":[[2019,2,11]],"date-time":"2019-02-11T03:49:36Z","timestamp":1549856976000},"page":"636-643","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":125,"title":["Systematic review with meta\u2010analysis: risk factors for recurrent primary sclerosing cholangitis after liver transplantation"],"prefix":"10.1111","volume":"49","author":[{"given":"Iris C.","family":"Steenstraten","sequence":"first","affiliation":[{"name":"Department of Gastroenterology and Hepatology Leiden University Medical Centre Leiden The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kerem","family":"Sebib Korkmaz","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology Leiden University Medical Centre Leiden The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Palak J.","family":"Trivedi","sequence":"additional","affiliation":[{"name":"National Institute for Health Research (NIHR) Birmingham Biomedical Research Centre Birmingham UK"},{"name":"University Hospitals Birmingham Birmingham UK"},{"name":"Institute of Immunology and Immunotherapy University of Birmingham Birmingham UK"},{"name":"Institute of Applied Health Research University of Birmingham UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akin","family":"Inderson","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology Leiden University Medical Centre Leiden The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6527-764X","authenticated-orcid":false,"given":"Bart","family":"van Hoek","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology Leiden University Medical Centre Leiden The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mar D. 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