{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T08:08:54Z","timestamp":1791274134811,"version":"4.1.0"},"reference-count":37,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2019,2,10]],"date-time":"2019-02-10T00:00:00Z","timestamp":1549756800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81470276"],"award-info":[{"award-number":["81470276"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81670092"],"award-info":[{"award-number":["81670092"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Aliment Pharmacol Ther"],"published-print":{"date-parts":[[2019,3]]},"abstract":"<jats:title>Summary<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Neuromodulators are considered potential therapeutic options for refractory gastro\u2010oesophageal reflux\u2010induced chronic cough.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>To compare the efficacy of gabapentin and baclofen in patients with suspected refractory gastro\u2010oesophageal reflux\u2010induced chronic cough.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Two hundred and thirty\u2010four patients with suspected refractory gastro\u2010oesophageal reflux\u2010induced chronic cough, who failed an 8\u2010week course of omeprazole and domperidone, were recruited into the open\u2010labelled study and randomly assigned to receive either gabapentin (maximum daily dose of 900\u00a0mg) or baclofen (maximum daily dose of 60\u00a0mg) for 8\u00a0weeks as add\u2010on therapy to the previous treatment. The primary end point was the successful rate of cough resolution; and the secondary end\u2010points included cough sensitivity to capsaicin and gastro\u2010oesophageal reflux disease questionnaire score and reported side effects.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      One hundred and eleven patients in the gabapentin group and 106 in the baclofen group completed the study. The overall success rate for cough resolution was comparable (57.3% vs 53.0%,\n                      <jats:italic>\u03c7<\/jats:italic>\n                      <jats:sup>2<\/jats:sup>\n                      \u00a0=\u00a00.357,\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0=\u00a00.550) between the two groups. In parallel, cough sensitivity to capsaicin and gastro\u2010oesophageal reflux disease questionnaire score decreased after treatment with either gabapentin or baclofen. However, gabapentin was associated with less frequent somnolence (20.5% vs 35.0%,\n                      <jats:italic>\u03c7<\/jats:italic>\n                      <jats:sup>2\u00a0<\/jats:sup>\n                      =\u00a06.156,\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0=\u00a00.013) and dizziness (11.1% vs 23.9%,\n                      <jats:italic>\u03c7<\/jats:italic>\n                      <jats:sup>2\u00a0<\/jats:sup>\n                      =\u00a06.654,\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0=\u00a00.010) than baclofen.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>\n                      Gabapentin and baclofen have similar therapeutic efficacy for suspected refractory gastro\u2010oesophageal reflux\u2010induced chronic cough. However, gabapentin may be preferable because of fewer side effects. Trial Register:\n                      <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"http:\/\/www.chictr.org\/\">http:\/\/www.chictr.org\/<\/jats:ext-link>\n                      ; No.: ChiCTR\u2010ONC\u201013003066.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/apt.15169","type":"journal-article","created":{"date-parts":[[2019,2,10]],"date-time":"2019-02-10T22:04:46Z","timestamp":1549836286000},"page":"714-722","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":66,"title":["Randomised clinical trial: gabapentin vs baclofen in the treatment of suspected refractory gastro\u2010oesophageal reflux\u2010induced chronic cough"],"prefix":"10.1111","volume":"49","author":[{"given":"Ran","family":"Dong","sequence":"first","affiliation":[{"name":"Department of Pulmonary and Critical Care Medicine Tongji Hospital, Tongji University School of Medicine Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xianghuai","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Pulmonary and Critical Care Medicine Tongji Hospital, Tongji University School of Medicine Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Yu","sequence":"additional","affiliation":[{"name":"Department of Pulmonary and Critical Care Medicine Tongji Hospital, Tongji University School of Medicine Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongmei","family":"Ding","sequence":"additional","affiliation":[{"name":"Department of Pulmonary and Critical Care Medicine Tongji Hospital, Tongji University School of Medicine Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Pan","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine Tongren Hospital, Shanghai Jiaotong University School of Medicine Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yiming","family":"Yu","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine Tongren Hospital, Shanghai Jiaotong University School of Medicine Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cuiqin","family":"Shi","sequence":"additional","affiliation":[{"name":"Department of Pulmonary and Critical Care Medicine Tongji Hospital, Tongji University School of Medicine Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiang","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Pulmonary and Critical Care Medicine Tongji Hospital, Tongji University School of Medicine Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mengru","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Pulmonary and Critical Care Medicine Tongji Hospital, Tongji University School of Medicine Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hanjing","family":"Lv","sequence":"additional","affiliation":[{"name":"Department of Pulmonary and Critical Care Medicine Tongji Hospital, Tongji University School of Medicine Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6612-7413","authenticated-orcid":false,"given":"Zhongmin","family":"Qiu","sequence":"additional","affiliation":[{"name":"Department of Pulmonary and Critical Care Medicine Tongji Hospital, Tongji University School of Medicine Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,2,10]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chest.2016.08.1458"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1378\/chest.12-0441"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1159\/000142942"},{"key":"e_1_2_7_5_1","first-page":"178","article-title":"A stepwise protocol for the treatment of refractory gastroesophageal reflux\u2010induced chronic cough","volume":"8","author":"Xu X","year":"2016","journal-title":"J Thorac Dis"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.5662\/wjm.v5.i3.149"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1186\/1745-9974-8-8"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v19.i27.4386"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(12)60776-4"},{"key":"e_1_2_7_10_1","first-page":"311","article-title":"Management of GERD\u2010related chronic cough","volume":"9","author":"Madanick RD","year":"2013","journal-title":"Gastroenterol Hepatol (N Y)"},{"key":"e_1_2_7_11_1","first-page":"273","article-title":"Validation of the reliability and clinical value of the simplified cough score","volume":"11","author":"Zhao T","year":"2012","journal-title":"Chinese J General Pract"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.94.07071246"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1136\/thx.47.6.441"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.12659\/MSM.889118"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.00101006"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1378\/chest.13-1634"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2036.2009.04142.x"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1843.2011.01952.x"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/crj.12124"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1023\/A:1023748225229"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2036.2007.03255.x"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1097\/00004836-200608000-00008"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1843.2008.01261.x"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.2008.02033.x"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2036.2007.03281.x"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjp.0703244"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2036.2003.01394.x"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1159\/000029232"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.1080\/14656566.2018.1462795"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.1186\/1745-9974-8-9"},{"key":"e_1_2_7_31_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00408-007-9048-4"},{"key":"e_1_2_7_32_1","doi-asserted-by":"publisher","DOI":"10.1136\/thoraxjnl-2015-207425"},{"key":"e_1_2_7_33_1","doi-asserted-by":"publisher","DOI":"10.5415\/apallergy.2014.4.1.3"},{"key":"e_1_2_7_34_1","first-page":"630","article-title":"Antinociceptive effects of gabapentin & its mechanism of action in experimental animal studies","volume":"135","author":"Kilic FS","year":"2012","journal-title":"Indian J Med Res"},{"key":"e_1_2_7_35_1","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.149.1.8111576"},{"key":"e_1_2_7_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pupt.2015.06.007"},{"key":"e_1_2_7_37_1","doi-asserted-by":"publisher","DOI":"10.5056\/jnm.2010.16.3.258"},{"key":"e_1_2_7_38_1","doi-asserted-by":"publisher","DOI":"10.1155\/2014\/307805"}],"container-title":["Alimentary Pharmacology &amp; Therapeutics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fapt.15169","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/apt.15169","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,8]],"date-time":"2023-09-08T18:40:40Z","timestamp":1694198440000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/apt.15169"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,2,10]]},"references-count":37,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2019,3]]}},"alternative-id":["10.1111\/apt.15169"],"URL":"https:\/\/doi.org\/10.1111\/apt.15169","archive":["Portico"],"relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.735073656.793556395","asserted-by":"object"}]},"ISSN":["0269-2813","1365-2036"],"issn-type":[{"value":"0269-2813","type":"print"},{"value":"1365-2036","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,2,10]]},"assertion":[{"value":"2018-12-09","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-01-11","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-02-10","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}