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Full length articles were selected for review, and secondary and tertiary bibliographies were developed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Hyperferritinemia is present in 4%\u201065% of patients with non\u2010alcoholic fatty liver disease, autoimmune hepatitis, chronic viral hepatitis, or alcoholic liver disease, and hepatic iron content is increased in 11%\u201052%. Heterozygosity for the C282Y mutation is present in 17%\u201048%, but this has not uniformly distinguished patients with adverse outcomes. An inappropriately low serum hepcidin level has characterised most chronic liver diseases with the exception of non\u2010alcoholic fatty liver disease, and the finding has been associated mainly with suppression of transcriptional activity of the hepcidin gene. Iron overload has been associated with oxidative stress, advanced fibrosis and decreased survival, and promising therapies beyond phlebotomy and oral iron chelation have included hepcidin agonists.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Iron dysregulation is common in chronic liver diseases other than hereditary haemochromatosis, and has been associated with liver toxicity and poor prognosis. Further evaluation of iron overload as a co\u2010morbid factor should identify the key pathogenic disturbances, establish the risk threshold for iron toxicity, and promote molecular interventions.<\/jats:p><\/jats:sec>","DOI":"10.1111\/apt.15173","type":"journal-article","created":{"date-parts":[[2019,2,14]],"date-time":"2019-02-14T07:44:34Z","timestamp":1550130274000},"page":"681-701","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":42,"title":["Review article: iron disturbances in chronic liver diseases other than haemochromatosis \u2013 pathogenic, prognostic, and therapeutic implications"],"prefix":"10.1111","volume":"49","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5024-3065","authenticated-orcid":false,"given":"Albert J.","family":"Czaja","sequence":"first","affiliation":[{"name":"Division of Gastroenterology and Hepatology Mayo Clinic College of Medicine and Science Rochester 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