{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T15:36:40Z","timestamp":1791128200668,"version":"4.1.0"},"reference-count":30,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2019,3,6]],"date-time":"2019-03-06T00:00:00Z","timestamp":1551830400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"name":"CJ Healthcare"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Aliment Pharmacol Ther"],"published-print":{"date-parts":[[2019,4]]},"abstract":"<jats:title>Summary<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Tegoprazan is a novel potassium\u2010competitive acid blocker that has a fast onset of action and can control gastric pH for a prolonged period, which could offer clinical benefit in acid\u2010related disorders.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aim<\/jats:title><jats:p>To confirm the non\u2010inferiority of tegoprazan to esomeprazole in patients with erosive oesophagitis (EE).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>In this multicentre, randomised, double\u2010blind, parallel\u2010group comparison study, 302 Korean patients with endoscopically confirmed EE (Los Angeles Classification Grades A\u2010D) were randomly allocated to either tegoprazan (50 or 100\u00a0mg) or esomeprazole (40\u00a0mg) treatment groups for 4 or 8\u00a0weeks. The primary endpoint was the cumulative proportion of patients with healed EE confirmed by endoscopy up to 8\u00a0weeks from treatment initiation. Symptoms, safety and tolerability were also assessed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The cumulative healing rates at week 8 were 98.9% (91\/92), 98.9% (90\/91) and 98.9% (87\/88) for tegoprazan 50\u00a0mg, tegoprazan 100\u00a0mg and esomeprazole 40\u00a0mg, respectively. Both doses of tegoprazan were non\u2010inferior to esomeprazole 40\u00a0mg. The incidence of adverse events was comparable among the groups, and tegoprazan was well\u2010tolerated.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Once daily administration of tegoprazan 50 or 100\u00a0mg showed non\u2010inferior efficacy in healing EE and tolerability to that of esomeprazole 40\u00a0mg.<\/jats:p><\/jats:sec>","DOI":"10.1111\/apt.15185","type":"journal-article","created":{"date-parts":[[2019,3,7]],"date-time":"2019-03-07T07:38:17Z","timestamp":1551944297000},"page":"864-872","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":141,"title":["Randomised phase 3 trial: tegoprazan, a novel potassium\u2010competitive acid blocker, vs. esomeprazole in patients with erosive oesophagitis"],"prefix":"10.1111","volume":"49","author":[{"given":"Kwang Jae","family":"Lee","sequence":"first","affiliation":[{"name":"Suwon 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