{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T18:09:17Z","timestamp":1791655757508,"version":"4.3.4"},"reference-count":48,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2019,3,18]],"date-time":"2019-03-18T00:00:00Z","timestamp":1552867200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Aliment Pharmacol Ther"],"published-print":{"date-parts":[[2019,5]]},"abstract":"<jats:title>Summary<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The frequency of eosinophilic oesophagitis (EoE) occurrence is escalating. Current diagnostic criteria recently proposed for the disease, determine that previous estimates of incidence and prevalence are outdated.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aim<\/jats:title><jats:p>To gauge the current incidence and prevalence of EoE by performing a systematic review of population\u2010based studies.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Three electronic databases were searched from their inception dates to September 2018. A total of 2386 documents were screened; 29 studies reported on the prevalence and incidence of EoE in the general population.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The pooled prevalence of EoE was 34.4 cases per 100\u00a0000 inhabitants (95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>, 23.1\u201047.5), and was higher for adults (42.2; 95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>, 31.1\u201055) than for children (34; 95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>, 22.3\u201049.2). The pooled EoE incidence rates were 6.6\/100\u00a0000 person\u2010years (95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>, 3\u201011.7) in children and 7.7\/100\u00a0000 (95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>, 1.8\u201017.8) in adults. No differences were found between North American and European studies using varied sources of data (insurance and administrative databases compared to hospital\u2010bases case series). Subgroup analysis according to risk of bias did not change results significantly. A steady rise in EoE incidence and prevalence rates was observed over time, comparing studies conducted under subsequent definitions for EoE. No significant publication bias was found.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>In a systematic review and meta\u2010analysis, we found a sharp increase, higher than previous estimates, in the incidence and prevalence of EoE in population based studies. Results from studies carried out in developed countries show broad consistency and provide evidence of increasing pooled prevalence and incidence of EoE rates over time.<\/jats:p><\/jats:sec>","DOI":"10.1111\/apt.15231","type":"journal-article","created":{"date-parts":[[2019,3,19]],"date-time":"2019-03-19T21:29:14Z","timestamp":1553030954000},"page":"1116-1125","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":306,"title":["Systematic review with meta\u2010analysis: the growing incidence and prevalence of eosinophilic oesophagitis in children and adults in population\u2010based studies"],"prefix":"10.1111","volume":"49","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6293-2570","authenticated-orcid":false,"given":"Pilar","family":"Navarro","sequence":"first","affiliation":[{"name":"School of Public Health, Physiotherapy and Sports Science University College Dublin Dublin 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