{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,21]],"date-time":"2026-05-21T10:22:34Z","timestamp":1779358954675,"version":"3.51.4"},"reference-count":50,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2019,4,11]],"date-time":"2019-04-11T00:00:00Z","timestamp":1554940800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Aliment Pharmacol Ther"],"published-print":{"date-parts":[[2019,5]]},"abstract":"<jats:title>Summary<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Mycophenolate mofetil is a commonly used salvage therapy for patients with autoimmune hepatitis (AIH).<\/jats:p><\/jats:sec><jats:sec><jats:title>Aim<\/jats:title><jats:p>To evaluate the predictors of response to mycophenolate rescue therapy to facilitate clinical decision making.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We performed a retrospective observational cohort study of AIH patients managed in 17 major Australian liver centres who received mycophenolate after an inadequate response or intolerance to corticosteroids with\/without thiopurine(s). Baseline demographic, clinical and laboratory variables were compared between responders and nonresponders. A multivariable logistic regression model was developed using forward selection to identify independent predictors of treatment response.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 105 patients received mycophenolate rescue therapy of whom 63 (60%) achieved biochemical remission. On univariable analysis, older age (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.003), INR\u00a0&lt;\u00a01.1 (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.02), and lower immunoglobulin gamma (IgG; <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.002) levels were associated with treatment response, while no association was found with cirrhosis status (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.07) or treatment indication (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.63). On multivariable analysis, lower pre\u2010treatment serum IgG level (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.01), higher age at commencing mycophenolate (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.01) and higher INR (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.03) were the only significant independent predictors. An IgG level &lt;17\u00a0g\/L had a positive and negative predictive value for response of 71% and 60% respectively, while age \u226554\u00a0years when commencing mycophenolate had a positive and negative predictive value for response of 80% and 59% respectively.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Mycophenolate remains an excellent treatment option for patients with AIH refractory to or intolerant of standard therapy with those most likely to benefit being older and\/or having lower pre\u2010treatment IgG levels.<\/jats:p><\/jats:sec>","DOI":"10.1111\/apt.15248","type":"journal-article","created":{"date-parts":[[2019,4,12]],"date-time":"2019-04-12T01:05:54Z","timestamp":1555031154000},"page":"1314-1322","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":34,"title":["Beneficial response to mycophenolate mofetil by patients with autoimmune hepatitis who have failed standard therapy, is predicted by older age and lower immunoglobulin G and INR levels"],"prefix":"10.1111","volume":"49","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1855-2757","authenticated-orcid":false,"given":"Amanda J.","family":"Nicoll","sequence":"first","affiliation":[{"name":"Melbourne Vic."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9015-7997","authenticated-orcid":false,"given":"Stuart K.","family":"Roberts","sequence":"additional","affiliation":[{"name":"Melbourne Vic."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ricky","family":"Lim","sequence":"additional","affiliation":[{"name":"Sydney NSW"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joanne","family":"Mitchell","sequence":"additional","affiliation":[{"name":"Melbourne Vic."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Martin","family":"Weltman","sequence":"additional","affiliation":[{"name":"Sydney 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