{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T21:02:32Z","timestamp":1791406952723,"version":"4.3.3"},"reference-count":27,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2019,4,8]],"date-time":"2019-04-08T00:00:00Z","timestamp":1554681600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Aliment Pharmacol Ther"],"published-print":{"date-parts":[[2019,6]]},"abstract":"<jats:title>Summary<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Liver cirrhosis is characterized by a silent phase until decompensation, which is defined by ascites, bleeding from esophageal varices or hepatic encephalopathy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aim<\/jats:title><jats:p>To compare the clinical course, patterns of survival and causes of death by etiology during long\u2010term follow\u2010up in a large population\u2010based cohort of patients with incident cirrhosis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We used population\u2010based medical registries for a cohort study of patients with liver cirrhosis diagnosed January 2001 to December 2010, in the Scania region of Sweden. Medical records were reviewed. Patients were classified according to etiology and clinical parameters were registered. Patients were followed until December 2017.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The cohort comprised 1317 patients, 631 were decompensated at diagnosis and 387 decompensated during follow\u2010up. The cumulative 10\u2010year incidence of decompensation, with death and transplantation as competing risks, was 89% in alcoholic cirrhosis, 58% in hepatitis C and 75% in cryptogenic cirrhosis. The lowest 10\u2010year transplantation\u2010free survival rates were found in cryptogenic cirrhosis (11%), alcohol\u2010related cirrhosis (18%) and alcohol combined with hepatitis C (12%). Autoimmune hepatitis cirrhosis showed the best 10\u2010year survival (53%) and hepatitis C, non\u2010alcoholic steatohepatitis, primary biliary cholangitis, and primary sclerosing cholangitis and other causes averaged 30%. Decompensation at diagnosis was an important predictor for death in all etiologies apart from alcoholic cirrhosis. 991 patients died and 91 were transplanted.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Our results show that the clinical course and survival in cirrhosis differ considerably by both etiology and state at diagnosis.<\/jats:p><\/jats:sec>","DOI":"10.1111\/apt.15255","type":"journal-article","created":{"date-parts":[[2019,4,8]],"date-time":"2019-04-08T09:09:16Z","timestamp":1554714556000},"page":"1421-1430","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":58,"title":["Clinical course and mortality by etiology of liver cirrhosis in Sweden: a population based, long\u2010term follow\u2010up study of 1317 patients"],"prefix":"10.1111","volume":"49","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0586-8063","authenticated-orcid":false,"given":"Emma","family":"Nilsson","sequence":"first","affiliation":[{"name":"Department of Clinical Sciences Lund University Lund Sweden"},{"name":"Gastroenterology Clinic, Sk\u00e5ne University Hospital Lund University Lund Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Harald","family":"Anderson","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences, Cancer Epidemiology Lund University Lund Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Konstantina","family":"Sargenti","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences Lund University Lund Sweden"},{"name":"Gastroenterology Clinic, Sk\u00e5ne University Hospital Lund University Lund Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefan","family":"Lindgren","sequence":"additional","affiliation":[{"name":"Gastroenterology Clinic, Sk\u00e5ne University Hospital Lund University Lund Sweden"},{"name":"Department of Clinical Sciences Lund University Malm\u00f6 Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hanne","family":"Prytz","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences Lund University Lund Sweden"},{"name":"Gastroenterology Clinic, Sk\u00e5ne University Hospital Lund University Lund Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,4,8]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2012.12.005"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12916-014-0145-y"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/apt.13635"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1080\/00365520902912571"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/apt.12721"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2007.05.024"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.28906"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2017.10.020"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.23478"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1080\/00365521.2018.1447599"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2036.2012.05108.x"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2036.2010.04473.x"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.23500"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.24491"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.21176"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2004.01.005"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2012.10.023"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1097\/MCG.0b013e3182284e13"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.4254\/wjh.v6.i7.504"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2005.10.013"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.27598"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1097\/MEG.0000000000000396"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-230X-14-166"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2018.08.013"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1111\/apt.13961"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.3109\/00365521.2014.983154"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2013.10.020"}],"container-title":["Alimentary Pharmacology &amp; 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