{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,5]],"date-time":"2025-10-05T12:22:49Z","timestamp":1759666969223,"version":"3.40.5"},"reference-count":28,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2019,4,24]],"date-time":"2019-04-24T00:00:00Z","timestamp":1556064000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Aliment Pharmacol Ther"],"published-print":{"date-parts":[[2019,6]]},"abstract":"<jats:title>Summary<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Colon ischaemia is a common disease which has been associated with various medications and comorbidities.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aim<\/jats:title><jats:p>To test the hypothesis that there are differences in the frequencies of these associations in older compared with younger patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A retrospective cohort study was performed of patients hospitalized with colon ischaemia at two major medical centres from 2005\u20102017. Clinical, colonoscopic and pathologic criteria were used to identify patients admitted with colon ischaemia; patients with other types of colitis were excluded. Demographic and medical data were extracted. Two cohorts were created: patients aged 18\u201064\u00a0years and patients\u00a0&gt;\u00a065\u00a0years. These were compared using SAS 14.3.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 788 patients were included, of which 271 (34.4%) were of ages 18\u201064\u00a0years, and 517 (66.6%) were 65\u00a0years old or older. In the older cohort, constipation\u2010inducing medications (83.8% vs 64.1%; <jats:italic>P\u00a0<\/jats:italic>=\u00a0&lt;0.0001), diuretics (38.1% vs 25.1%; <jats:italic>P\u00a0<\/jats:italic>=\u00a0&lt;0.001) and nonsteroidal anti\u2010inflammatory drugs (58% vs 41.5%; <jats:italic>P\u00a0<\/jats:italic>=\u00a0&lt;0.0001) were more common than in the younger cohort. Antipsychotic medication use was more common in the younger cohort (10.4% vs 5.4%; <jats:italic>P<\/jats:italic>\u00a0=\u00a00.01). There was a higher percentage of younger patients with a history of hypercoaguable state (1.9% vs 0.2%; <jats:italic>P<\/jats:italic>\u00a0=\u00a00.03) and dialysis dependence (22.9% vs 8.7%; <jats:italic>P\u00a0<\/jats:italic>=\u00a0&lt;0.01), while a higher percentage of patients in the older cohort had a history of chronic obstructive pulmonary disease (12% vs 6.3%; <jats:italic>P<\/jats:italic>\u00a0=\u00a00.01) or atrial fibrillation (18.9% vs 10.3%; <jats:italic>P\u00a0<\/jats:italic>=\u00a0&lt;0.01).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Our study shows that older patients are more likely to have colon ischaemia\u2010associated conditions that are chronic and complex, while younger patients are more likely to have acute colon ischaemia\u2010associated conditions.<\/jats:p><\/jats:sec>","DOI":"10.1111\/apt.15268","type":"journal-article","created":{"date-parts":[[2019,4,25]],"date-time":"2019-04-25T01:21:40Z","timestamp":1556155300000},"page":"1502-1508","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Older patients are significantly more likely to have colon ischaemia\u2010associated conditions that are chronic and complex"],"prefix":"10.1111","volume":"49","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8061-6419","authenticated-orcid":false,"given":"Michael","family":"Silverman","sequence":"first","affiliation":[{"name":"Department of Internal Medicine Cleveland Clinic Foundation Cleveland OH"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Olga C.","family":"Aroniadis","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology Albert Einstein College of Medicine, Montefiore Medical Center Bronx 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Connecticut"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Abdul Qadir","family":"Bhutta","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Yale New Haven Hospital New Haven Connecticut"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lawrence J.","family":"Brandt","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology Albert Einstein College of Medicine, Montefiore Medical Center Bronx 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