{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T01:06:56Z","timestamp":1792199216801,"version":"4.4.0"},"reference-count":40,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2019,5,10]],"date-time":"2019-05-10T00:00:00Z","timestamp":1557446400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004837","name":"Ministerio de Ciencia e Innovaci\u00f3n","doi-asserted-by":"publisher","award":["IPT\u20102011\u20100952\u2010900000"],"award-info":[{"award-number":["IPT\u20102011\u20100952\u2010900000"]}],"id":[{"id":"10.13039\/501100004837","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002924","name":"Federaci\u00f3n Espa\u00f1ola de Enfermedades Raras","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002924","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100006466","name":"Corporaci\u00f3n Tecnol\u00f3gica de Andaluc\u00eda","doi-asserted-by":"publisher","award":["1737\/0118"],"award-info":[{"award-number":["1737\/0118"]}],"id":[{"id":"10.13039\/501100006466","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Aliment Pharmacol Ther"],"published-print":{"date-parts":[[2019,6]]},"abstract":"<jats:title>Summary<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Treatment for coeliac disease is a lifelong strict gluten\u2010free diet. Although guidelines recommend regular follow\u2010up with dietary interviews and coeliac serology, these methods may be inaccurate.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aim<\/jats:title><jats:p>To evaluate the usefulness of faecal gluten immunogenic peptides to support the diagnosis and to determine the adherence to the gluten\u2010free diet in coeliac children.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Multicentre prospective observational study including 64 coeliac children. Faecal gluten peptides, and tissue transglutaminase and deamidated gliadin peptide antibodies were analyzed at diagnosis, and 6, 12 and 24\u00a0months thereafter. Gluten consumption was estimated from gluten peptide levels.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Most children (97%) had detectable gluten peptides at diagnosis. On a gluten\u2010free diet, the rate of gluten peptides increased from 13% at 6\u00a0months to 25% at 24\u00a0months. Mean estimated gluten exposure dropped from 5543\u00a0mg\/d at diagnosis to 144\u00a0mg\/d at 6\u00a0months, then increased to 606\u00a0mg\/d by 24\u00a0months. In contrast, deamidated gliadin peptide antibodies normalised and only 20% had elevated tissue transglutaminase antibody by 24\u00a0months. The elevation of tissue transglutaminase antibody was more prolonged in patients with detectable gluten peptides (<jats:italic>P\u00a0<\/jats:italic>&lt;<jats:italic>\u00a0<\/jats:italic>0.05). Nevertheless, absolute levels of tissue transglutaminase antibody had low sensitivity to identify patients with detectable gluten peptides (<jats:italic>P\u00a0<\/jats:italic>&gt;<jats:italic>\u00a0<\/jats:italic>0.1). Dietitian assessment was only moderately correlated with gluten peptide detection (\u03ba\u00a0=\u00a00.5).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Faecal gluten peptides testing may guide treatment of coeliac disease prior to diagnosis and during the assessment diet adherence. Further studies could determine if early identification of gluten exposure reduces the need for expensive\/invasive investigations for non\u2010responsive coeliac disease. ClinicalTrials.gov Number: <jats:styled-content style=\"fixed-case\">NCT<\/jats:styled-content>02711397.<\/jats:p><\/jats:sec>","DOI":"10.1111\/apt.15277","type":"journal-article","created":{"date-parts":[[2019,5,10]],"date-time":"2019-05-10T08:59:55Z","timestamp":1557478795000},"page":"1484-1492","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":61,"title":["Prospective longitudinal study: use of faecal gluten immunogenic peptides to monitor children diagnosed with coeliac disease during transition to a gluten\u2010free diet"],"prefix":"10.1111","volume":"49","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4982-273X","authenticated-orcid":false,"given":"Isabel","family":"Comino","sequence":"first","affiliation":[{"name":"Sevilla Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ver\u00f3nica","family":"Segura","sequence":"additional","affiliation":[{"name":"Sevilla 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