{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T18:38:54Z","timestamp":1790707134842,"version":"4.1.0"},"reference-count":48,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2019,5,22]],"date-time":"2019-05-22T00:00:00Z","timestamp":1558483200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Italian Society of Internal Medicine","award":["research prize won by Dr. Marco Vincenzo Lenti in 2017"],"award-info":[{"award-number":["research prize won by Dr. Marco Vincenzo Lenti in 2017"]}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Aliment Pharmacol Ther"],"published-print":{"date-parts":[[2019,7]]},"abstract":"<jats:title>Summary<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Autoimmune atrophic gastritis (AAG) is characterised by a wide clinical spectrum that could delay its diagnosis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aims<\/jats:title><jats:p>To quantify the diagnostic delay in patients suffering from AAG and to explore possible risk factors for longer diagnostic delay.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Consecutive patients with AAG evaluated at our gastroenterological outpatient clinic between 2009 and 2018 were included. Diagnostic delay was estimated as the time lapse occurring between the appearance of the first likely symptoms, laboratory alterations, and other clues indicative of AAG and the final diagnosis. Patient\u2010dependent and physician\u2010dependent diagnostic delays were also assessed. Multivariable regression models were fitted.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>291 patients with AAG (mean age at diagnosis 61\u00a0\u00b1\u00a015\u00a0years; F:M ratio\u00a0=\u00a02.3:1) were included. The median overall diagnostic delay was 14\u00a0months (interquartile range [IQR] 4\u201041). Factors associated with longer median overall diagnostic delay were female sex (17\u00a0months, IQR 5\u201048), having a previous misdiagnosis (36\u00a0months, IQR 17\u2010125) and a history of infertility\/miscarriages (33\u00a0months, IQR 8\u2010120), whereas a higher level of education was associated with longer patient\u2010dependent diagnostic delay (4\u00a0months, IQR 1\u201012). First evaluation by a gastroenterologist was associated with a median longer diagnostic delay (6\u00a0months, IQR 2\u201015) compared to an internist (3\u00a0months, IQR 3\u201031) and a haematologist (1\u00a0month, IQR 0\u20102). Age, socioeconomic or marital status did not affect the diagnostic delay.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>AAG is burdened by substantial diagnostic delay, especially in female patients, and due to lack of awareness, particularly among gastroenterologists. Uncommon vitamin B12 deficiency\u2010related manifestations are overlooked and may prolong the diagnostic delay.<\/jats:p><\/jats:sec>","DOI":"10.1111\/apt.15317","type":"journal-article","created":{"date-parts":[[2019,5,22]],"date-time":"2019-05-22T10:20:25Z","timestamp":1558520425000},"page":"167-175","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":106,"title":["Determinants of diagnostic delay in autoimmune atrophic gastritis"],"prefix":"10.1111","volume":"50","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6654-4911","authenticated-orcid":false,"given":"Marco Vincenzo","family":"Lenti","sequence":"first","affiliation":[{"name":"First Department of Internal Medicine San Matteo Hospital Foundation, University of Pavia Pavia Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emanuela","family":"Miceli","sequence":"additional","affiliation":[{"name":"First Department of Internal Medicine San Matteo 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