{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,12]],"date-time":"2026-05-12T00:18:59Z","timestamp":1778545139723,"version":"3.51.4"},"reference-count":32,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2019,6,6]],"date-time":"2019-06-06T00:00:00Z","timestamp":1559779200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000265","name":"Medical Research Council","doi-asserted-by":"publisher","award":["MR\/J006742\/1"],"award-info":[{"award-number":["MR\/J006742\/1"]}],"id":[{"id":"10.13039\/501100000265","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006662","name":"National Institute on Handicapped Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100006662","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Aliment Pharmacol Ther"],"published-print":{"date-parts":[[2019,8]]},"abstract":"<jats:title>Summary<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Rifaximin reduces the risk of overt hepatic encephalopathy (HE) and is associated with significant reductions in hospitalisations and 30\u2010day readmissions.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aim<\/jats:title><jats:p>To examine the outcomes of patients listed for liver transplantation with a diagnosis of HE on rifaximin compared to those na\u00efve to the drug.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Patient records of those listed for liver transplantation over a 2\u2010year period were retrospectively reviewed. Patients were included if they had at least two episodes of overt HE resulting in hospitalisation or were encephalopathic at the time of assessment.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Of the 622 patients listed for transplantation, 101 had HE. Sixty\u2010six patients were treated with rifaximin and 35 were na\u00efve at listing. The use of concurrent lactulose was not significantly different between groups. Median MELD score was similar (15 [14\u201016)] rifaximin\u2010treated and 16 [14\u201018] rifaximin\u2010na\u00efve). Patients on the waiting list treated with rifaximin had reduced all\u2010cause admissions, episodes of spontaneous bacterial peritonitis and variceal bleeding. Mean length of stay was 9 days (95% CI 6\u201012) in the rifaximin\u2010treated group vs 14 (95% CI 7\u201021) in the rifaximin\u2010na\u00efve group. Multivariate regression analysis demonstrated that rifaximin was independently associated with an increase in average days to readmission (adjusted effect estimate 71, 95% CI 3\u2010140\u00a0days) and reduced likelihood of requirement for prioritisation on the waiting list (odds ratio 0.29; 95% CI 0.89\u20100.93).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Rifaximin prescribed for HE in patients listed for liver transplantation improved outcomes with significant reduction in admissions related to spontaneous bacterial peritonitis, ascites and variceal bleeding.<\/jats:p><\/jats:sec>","DOI":"10.1111\/apt.15326","type":"journal-article","created":{"date-parts":[[2019,6,6]],"date-time":"2019-06-06T14:49:30Z","timestamp":1559832570000},"page":"435-441","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":59,"title":["Rifaximin reduces the incidence of spontaneous bacterial peritonitis, variceal bleeding and all\u2010cause admissions in patients on the liver transplant waiting list"],"prefix":"10.1111","volume":"50","author":[{"given":"Shayon","family":"Salehi","sequence":"first","affiliation":[{"name":"Institute of Liver Studies and Transplantation King's College Hospital London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas H.","family":"Tranah","sequence":"additional","affiliation":[{"name":"Institute of Liver Studies and Transplantation King's College Hospital London UK"},{"name":"Liver Sciences, Faculty of Life Sciences and Medicine, 1st Floor James Black Centre, School of Immunology and Microbial Sciences King's College London London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Samuel","family":"Lim","sequence":"additional","affiliation":[{"name":"Institute of Liver Studies and Transplantation King's College Hospital London 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