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However, they requently fail related to the inability of patients to implement lasting changes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>To evaluate the effects of a short, web\u2010based, individualised exercise program on non\u2010invasive markers of hepatic steatosis, inflammation and fibrosis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Patients with histologically confirmed NAFLD underwent an 8\u2010week, web\u2010based, individualised exercise program that contained bidirectional feedback.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Forty\u2010four patients entered the study and 41 completed the assigned training goal (93.2%). In the completer population, 8\u00a0weeks of individualised exercise increased the VO\n                      <jats:sub>2peak<\/jats:sub>\n                      by 12.2% compared to baseline (\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0&lt;\u00a0.001). ALT and AST decreased by 14.3% (\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0=\u00a0.002) and 18.2% (\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0&lt;\u00a0.001) and remained at this level until follow\u2010up 12\u00a0weeks after the intervention. Markers of inflammation including hsCRP, ferritin, and M30 decreased. In parallel, gut microbiota exhibited increased metagenomic richness (\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0&lt;\u00a0.05) and at the taxonomic levels Bacteroidetes and Euryarchaeota increased whereas Actinobacteria phylum decreased. Surrogate scores of steatosis and fibrosis including the fatty liver index (FLI), FiB\u20104, APRI and transient elastography showed significant reductions. In parallel, a marker of procollagen\u20103 turnover (PRO\u2010C3) decreased while C4M2, reflecting type IV collagen, degradation increased suggesting beneficial hepatic fibrosis remodelling from exercise. Also, an enhancement in health\u2010related quality of life was reported.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The current study underlines the plausibility and potential of an 8\u00a0week individualised web\u2010based exercise program in NAFLD.<\/jats:p>\n                    <jats:p>\n                      Clinical trial number\n                      <jats:bold>:<\/jats:bold>\n                      NCT02526732\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/apt.15427","type":"journal-article","created":{"date-parts":[[2019,7,25]],"date-time":"2019-07-25T03:29:45Z","timestamp":1564025385000},"page":"930-939","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":88,"title":["Improvement of non\u2010invasive markers of NAFLD from an individualised, web\u2010based exercise program"],"prefix":"10.1111","volume":"50","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2145-1623","authenticated-orcid":false,"given":"Yvonne","family":"Huber","sequence":"first","affiliation":[{"name":"Department of Internal Medicine I University Medical Centre of the Johannes Gutenberg\u2010University Mainz Mainz Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Pfirrmann","sequence":"additional","affiliation":[{"name":"Department of Sports Medicine, Rehabilitation and Prevention Johannes Gutenberg\u2010University Mainz Mainz Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ines","family":"Gebhardt","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine I University Medical Centre of the Johannes Gutenberg\u2010University Mainz Mainz 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