{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T15:02:43Z","timestamp":1790694163936,"version":"4.1.0"},"reference-count":37,"publisher":"Wiley","issue":"11-12","license":[{"start":{"date-parts":[[2019,10,15]],"date-time":"2019-10-15T00:00:00Z","timestamp":1571097600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001665","name":"Agence Nationale de la Recherche","doi-asserted-by":"publisher","award":["ANR\u201015\u2010CE36\u20100006\u201001"],"award-info":[{"award-number":["ANR\u201015\u2010CE36\u20100006\u201001"]}],"id":[{"id":"10.13039\/501100001665","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Aliment Pharmacol Ther"],"published-print":{"date-parts":[[2019,12]]},"abstract":"<jats:title>Summary<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Children born to mothers with IBD may be exposed to anti\u2010TNF\u03b1 agents antenatally. Current European guidelines recommend postponing live vaccines until after 6\u00a0months of life in this population. Data on the safety of live vaccines administration in the first year of life of these children are sparse with one reported fatality following bacillus Calmette\u2010Guerin (BCG) administration.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>To describe the use and safety of vaccines administered in children born to mothers with IBD and exposed antenatally to anti\u2010TNF\u03b1 agents<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Data from children born to mothers with IBD between 2013 and 2014 were collected retrospectively from the French Health Insurance Database. Vaccines recommended before or at 1\u00a0year of age were considered.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Among 4741 children, 670 (14.1%) were exposed to anti\u2010TNF\u03b1 agents antenatally, with concomitant thiopurines in 16.0% (n\u00a0=\u00a0107) and steroids in 19.3% (n\u00a0=\u00a0214). Among these 670 children, 315 (47%) were exposed up to delivery. Exposed children were less likely than non\u2010exposed to receive BCG (88\/670, 13.1% vs 780\/4071, 19.2% respectively,\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0&lt;\u00a0.05) and received it later in life (months, mean\u00a0\u00b1\u00a0SD, 4.3\u00a0\u00b1\u00a03.9 and 2.4\u00a0\u00b1\u00a02.9 respectively,\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0&lt;\u00a0.001). In exposed children, 64\/88 (73%) received BCG vaccination before 6\u00a0months of age, but with no BCG\u2010related severe adverse event observed during the first year. Uptake of other vaccines recommended before 6\u00a0months was above 85% in both groups.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>In children exposed antenatally to anti\u2010TNF\u03b1 agents, vaccinations are often not postponed in keeping with the recommendations, but no BCG\u2010related severe adverse events were reported in children vaccinated before 6\u00a0months of life.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/apt.15504","type":"journal-article","created":{"date-parts":[[2019,10,16]],"date-time":"2019-10-16T00:44:55Z","timestamp":1571186695000},"page":"1181-1188","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":31,"title":["Safety of first year vaccination in children born to mothers with inflammatory bowel disease and exposed\n                    <i>in utero<\/i>\n                    to anti\u2010TNF\u03b1 agents: a French nationwide population\u2010based cohort"],"prefix":"10.1111","volume":"50","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9024-293X","authenticated-orcid":false,"given":"Maxime","family":"Luu","sequence":"first","affiliation":[{"name":"Clinical Investigation Center (INSERM 1432), Dijon \u2010 Bourgogne University Hospital Dijon France"},{"name":"UFR Sciences Sant\u00e9 Universit\u00e9 Bourgogne Franche\u2010Comt\u00e9 Dijon France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eric","family":"Benzenine","sequence":"additional","affiliation":[{"name":"Biostatistics and Bioinformatics Department Dijon Bourgogne University Hospital Dijon France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1798-5526","authenticated-orcid":false,"given":"Alan","family":"Barkun","sequence":"additional","affiliation":[{"name":"The McGill University Health Centre Montreal General Hospital McGill University Montreal Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Muriel","family":"Doret","sequence":"additional","affiliation":[{"name":"H\u00f4pital Femme\u2010M\u00e8re\u2010Enfant Service de Gyn\u00e9cologie Obst\u00e9trique Bron France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christophe","family":"Michiels","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology Dijon Bourgogne University Hospital Dijon France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thibault","family":"Degand","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology Dijon Bourgogne University Hospital Dijon France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Catherine","family":"Quantin","sequence":"additional","affiliation":[{"name":"Biostatistics and Bioinformatics Department Dijon Bourgogne University Hospital Dijon France"},{"name":"Biostatistics, 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