{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T11:00:28Z","timestamp":1792839628744,"version":"4.5.0"},"reference-count":34,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2019,10,17]],"date-time":"2019-10-17T00:00:00Z","timestamp":1571270400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Intercept Pharmaceuticals"},{"name":"Foundation for Liver and Gastrointestinal Research"},{"name":"Cymabay Therapeutics Inc."}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Aliment Pharmacol Ther"],"published-print":{"date-parts":[[2019,11]]},"abstract":"<jats:title>Summary<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Fibrosis stage predicts prognosis in patients with chronic liver disease independent of aetiology, although its precise role in risk stratification in patients with primary biliary cholangitis (PBC) remains undefined.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aim<\/jats:title><jats:p>To assess the utility of baseline fibrosis stage in predicting long\u2010term outcomes in the context of biochemical risk stratification<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>In a large and globally representative cohort of patients with PBC, liver biopsies performed from 1980 to 2014 were evaluated. The predictive ability of histologic fibrosis stage in addition to treatment response at 1\u00a0year (Toronto\/Paris\u2010II criteria), as well as non\u2010invasive markers of fibrosis (AST\/ALT ratio [AAR], AST to platelet ratio index [APRI], FIB\u20104), for transplant\u2010free survival was assessed with Cox proportional\u2010hazards models.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>There were 1828 patients with baseline liver biopsy. Advanced histologic fibrosis (stage 3\/4) was an independent predictor of survival in addition to non\u2010invasive measures of fibrosis with the hazard ratios ranging from 1.59 to 2.73 (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a0.001). Patients with advanced histologic fibrosis stage had worse survival despite biochemical treatment response, with a 10\u2010year survival of 76.0%\u201086.6% compared to 94.5%\u201095.1% depending on the treatment response criteria used. Poor correlations were observed between non\u2010invasive measures of fibrosis and histologic fibrosis stage.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Assessment of fibrosis stage grants prognostic value beyond biochemical treatment response at 1\u00a0year. This highlights the need to incorporate fibrosis stage in individual risk stratification in patients with PBC, partly to identify those that may derive benefit from novel therapies.<\/jats:p><\/jats:sec>","DOI":"10.1111\/apt.15533","type":"journal-article","created":{"date-parts":[[2019,10,17]],"date-time":"2019-10-17T09:19:05Z","timestamp":1571303945000},"page":"1127-1136","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":114,"title":["Fibrosis stage is an independent predictor of outcome in primary biliary cholangitis despite biochemical treatment response"],"prefix":"10.1111","volume":"50","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7634-4537","authenticated-orcid":false,"given":"Carla F.","family":"Murillo Perez","sequence":"first","affiliation":[{"name":"Toronto Ontario Canada"},{"name":"Rotterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gideon 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