{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T00:44:44Z","timestamp":1787013884952,"version":"build-2736575974"},"reference-count":34,"publisher":"Wiley","issue":"11-12","license":[{"start":{"date-parts":[[2019,10,30]],"date-time":"2019-10-30T00:00:00Z","timestamp":1572393600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Aliment Pharmacol Ther"],"published-print":{"date-parts":[[2019,12]]},"abstract":"<jats:title>Summary<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Current guidelines in primary biliary cholangitis ( PBC) recommend routine screening for symptoms. However, at present there are no validated practical tools suitable for screening use in practice.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>To develop a short quality of life questionnaire for PBC<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>The short PBC HRQL questionnaire was derived and validated by analysing the PBC\u201040 questionnaires from the UK\u2010PBC Research Cohort. Construct validity was assessed using the European Quality of Life Five Dimensions (EQ5D) questionnaire. Test\u2010retest analysis was done by asking a subgroup of patients to complete the questionnaire twice within 2\u20104\u00a0weeks.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      A total of 2219 patients completed PBC\u201040 questionnaire in 2013. Stepwise regression identified 10 questions that contributed to more than 95% of the PBC\u201040 score variance and covered the main domains of PBC. The short HRQL questionnaire, PBC\u201010, had good internal consistency (Cronbach's \u03b1 0.905) and item\u2010total correlations. PBC\u201010 demonstrated no ceiling effects but a floor effect was noted. Further validation on 2502 patients who completed the PBC questionnaire in 2017 confirmed the psychometric properties of PBC\u201010. Further analysis on 186 patients showed that PBC\u201010 demonstrated good internal consistency (Cronbach's \u03b1\u00a0=\u00a00.936), had good reproducibility (intra\u2010class correlation coefficient\u00a0=\u00a00.945), good correlation with the EQ5D (\n                      <jats:italic>r<\/jats:italic>\n                      \u00a0=\u00a0.736), and was responsive to change. A change of 4 points in the PBC\u201010 score would be considered clinically important.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>PBC\u201010 is a short and valid questionnaire for assessing the HRQL in patients with PBC in clinical practice.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/apt.15554","type":"journal-article","created":{"date-parts":[[2019,10,30]],"date-time":"2019-10-30T09:35:10Z","timestamp":1572428110000},"page":"1223-1231","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":22,"title":["PBC\u201010: a short quality of life measure for clinical screening in primary biliary cholangitis"],"prefix":"10.1111","volume":"50","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6340-8244","authenticated-orcid":false,"given":"Laith","family":"Alrubaiy","sequence":"first","affiliation":[{"name":"St Mark\u2019s Hospital London UK"},{"name":"Swansea University Medical School Swansea UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"George","family":"Mells","sequence":"additional","affiliation":[{"name":"Department of Medical Genetics University of Cambridge Cambridge UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steven","family":"Flack","sequence":"additional","affiliation":[{"name":"Department of Medical Genetics University of Cambridge Cambridge UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Helen","family":"Bosomworth","sequence":"additional","affiliation":[{"name":"Institute of Cellular Medicine Newcastle University Newcastle UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hayley","family":"Hutchings","sequence":"additional","affiliation":[{"name":"Swansea University Medical School Swansea UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John","family":"Williams","sequence":"additional","affiliation":[{"name":"Swansea University Medical School Swansea UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Jones","sequence":"additional","affiliation":[{"name":"Institute of Cellular Medicine Newcastle University Newcastle UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"on behalf of the UK\u2010PBC Research Consortium","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,10,30]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2017-315259"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/MEG.0b013e328353753d"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1136\/gut.2005.065862"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/jnu.12146"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/liv.13919"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(10)61965-4"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2005.12.012"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/apt.13794"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2017.03.022"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2014.12.005"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199105303242204"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1586\/17512433.2015.1092381"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1177\/2050640614558345"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1093\/acprof:oso\/9780199231881.001.0001"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11136-010-9606-8"},{"key":"e_1_2_7_17_1","unstructured":"NunnallyJC.Psychometric Theory.New York NY:McGraw\u2010Hill;1967:xiii 640\u2010xiii 640."},{"key":"e_1_2_7_18_1","first-page":"2","article-title":"A note on the multiplying factors for various chi square approximations","volume":"16","author":"Bartlett MS","year":"1954","journal-title":"J Roy Stat Soc"},{"key":"e_1_2_7_19_1","unstructured":"ZimmermanTF StreinerDL NormanGR CairneyJ.Health Measurement Scales: A Practical Guide to their Development and Use.5th ed.Oxford:Oxford University Press;2014."},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpsychores.2010.01.006"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11136-017-1765-4"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1097\/00006199-198611000-00017"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1002\/nur.20147"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0197-2456(05)80019-4"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1037\/0033-2909.112.1.155"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/0197-2456(89)90005-6"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.4065\/77.4.371"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1177\/0049124106292354"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02291575"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.1207\/s15327906mbr0102_10"},{"key":"e_1_2_7_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2018.12.007"},{"key":"e_1_2_7_32_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2036.1998.00395.x"},{"key":"e_1_2_7_33_1","doi-asserted-by":"publisher","DOI":"10.1111\/ctr.13434"},{"key":"e_1_2_7_34_1","doi-asserted-by":"publisher","DOI":"10.1111\/apt.15060"},{"key":"e_1_2_7_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bpg.2018.06.007"}],"container-title":["Alimentary Pharmacology &amp; Therapeutics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fapt.15554","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/apt.15554","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,7]],"date-time":"2023-09-07T09:40:53Z","timestamp":1694079653000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/apt.15554"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,10,30]]},"references-count":34,"journal-issue":{"issue":"11-12","published-print":{"date-parts":[[2019,12]]}},"alternative-id":["10.1111\/apt.15554"],"URL":"https:\/\/doi.org\/10.1111\/apt.15554","archive":["Portico"],"relation":{},"ISSN":["0269-2813","1365-2036"],"issn-type":[{"value":"0269-2813","type":"print"},{"value":"1365-2036","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,10,30]]},"assertion":[{"value":"2019-08-06","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-10-02","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-10-30","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}