{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,24]],"date-time":"2026-08-24T18:28:32Z","timestamp":1787596112479,"version":"build-2736575974"},"reference-count":49,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2019,11,27]],"date-time":"2019-11-27T00:00:00Z","timestamp":1574812800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000098","name":"NIH Clinical Center","doi-asserted-by":"publisher","award":["R01CA196692"],"award-info":[{"award-number":["R01CA196692"]}],"id":[{"id":"10.13039\/100000098","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000098","name":"NIH Clinical Center","doi-asserted-by":"publisher","award":["T32 DK007634"],"award-info":[{"award-number":["T32 DK007634"]}],"id":[{"id":"10.13039\/100000098","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000738","name":"U.S. Department of Veterans Affairs","doi-asserted-by":"publisher","award":["I01CX001156"],"award-info":[{"award-number":["I01CX001156"]}],"id":[{"id":"10.13039\/100000738","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Aliment Pharmacol Ther"],"published-print":{"date-parts":[[2020,2]]},"abstract":"<jats:title>Summary<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The real\u2010world, long\u2010term benefits of sustained virologic response (SVR) on the risk of variceal bleeding remain unclear.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aim<\/jats:title><jats:p>To assess the association between DAA\u2010induced SVR and post\u2010treatment variceal bleeding<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We identified patients who initiated DAA\u2010only anti\u2010viral treatments in the United States Veterans Affairs healthcare system from 2013 to 2015. We followed patients until 1 January 2019 for the development of gastro\u2010oesophageal variceal bleeding defined by diagnostic codes. We used multivariable Cox proportional hazards regression to assess the association between SVR and development of variceal bleeding, adjusting for potential confounders.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Among 33\u00a0582 DAA\u2010treated patients, 549 (1.6%) developed variceal bleeding after treatment (mean follow\u2010up 3.1\u00a0years). Compared to no SVR, SVR was associated with a significantly lower incidence of variceal bleeding among all patients (0.46 vs 1.26 per 100 patient\u2010years, adjusted hazard ratio [AHR] 0.66, 95% CI 0.52\u20100.83), among patients with pre\u2010treatment cirrhosis (1.55 vs 2.96 per 100 patient\u2010years, AHR 0.73, 95% CI 0.57\u20100.93) and among patients without pre\u2010treatment cirrhosis (0.07 vs 0.29 per 100 patient\u2010years, AHR 0.33, 95% CI 0.17\u20100.65). The risk of variceal bleeding after treatment was lower in those who achieved SVR vs no SVR among patients who had non\u2010bleeding varices (3.5 vs 4.9 per 100 patient\u2010years) or bleeding varices (12.9 vs 16.4 per 100 patient\u2010years) diagnosed before treatment, but these differences were not statistically significant in adjusted analyses.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>DAA\u2010induced SVR is independently associated with a lower risk of variceal bleeding during long\u2010term follow\u2010up in patients with and without pre\u2010treatment cirrhosis. These findings demonstrate an important real\u2010world benefit of DAA treatment.<\/jats:p><\/jats:sec>","DOI":"10.1111\/apt.15586","type":"journal-article","created":{"date-parts":[[2019,11,27]],"date-time":"2019-11-27T08:58:12Z","timestamp":1574845092000},"page":"364-373","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":33,"title":["Hepatitis C eradication with direct\u2010acting anti\u2010virals reduces the risk of variceal bleeding"],"prefix":"10.1111","volume":"51","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7163-2062","authenticated-orcid":false,"given":"Andrew M.","family":"Moon","sequence":"first","affiliation":[{"name":"Division of Gastroenterology and Hepatology Department of Medicine University of North Carolina Chapel Hill NC USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pamela K.","family":"Green","sequence":"additional","affiliation":[{"name":"Research and Development Veterans Affairs 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