{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T00:44:46Z","timestamp":1787013886426,"version":"build-2736575974"},"reference-count":39,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2020,1,14]],"date-time":"2020-01-14T00:00:00Z","timestamp":1578960000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Aliment Pharmacol Ther"],"published-print":{"date-parts":[[2020,2]]},"abstract":"<jats:title>Summary<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Significant hepatic fibrosis is associated with higher mortality. However, data on the estimated prevalence of liver fibrosis in the general population are scarce.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>To use magnetic resonance elastography (MRE) to investigate the prevalence of hepatic fibrosis in a Korean health check\u2010up clinic cohort.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We enrolled 2170 participants at our health check\u2010up clinic between January 2015 and May 2018, all of whom had MR with chemical shift technique and MRE. The primary objective was to estimate the prevalence of liver fibrosis. For generalisation, sex\u2010 and age\u2010standardised prevalence was calculated based on the Korean Statistical Information Service (KOSIS) during the period 2015\u20102018.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The prevalence of F2 (\u22653.0\u00a0kPa) and F3 (\u22653.6\u00a0kPa) in the overall cohort was 5.1% and 1.3% respectively (sex\u2010 and age\u2010adjusted prevalence of 3.8% and 1.3%). Non\u2010alcoholic fatty liver disease (NAFLD) prevalence (&gt;5% fat fraction) was 27.7% in the average risk population (after excluding alcohol use and viral hepatitis), and the prevalence of significant and advanced fibrosis in NAFLD participants was 8.0% and 1.5% respectively. In participants with diabetes, 12.5% had \u2265F2 and 4.3% \u2265F3. In participants with NAFLD plus diabetes, 24.1% had \u2265F2 and 6.0% \u2265F3. On multivariate analysis, only age, insulin, diabetes and fatty liver on MR were independently associated with significant fibrosis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>In a Korean health check\u2010up clinic setting, the prevalence of significant and advanced liver fibrosis was 5.1% and 1.3% (sex\u2010 and age\u2010adjusted prevalence of 3.8% and 1.3%). The prevalence of advanced liver fibrosis was five times higher for diabetic participants with NAFLD.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/apt.15626","type":"journal-article","created":{"date-parts":[[2020,1,16]],"date-time":"2020-01-16T05:33:05Z","timestamp":1579152785000},"page":"388-396","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":32,"title":["Prevalence of significant hepatic fibrosis using magnetic resonance elastography in a health check\u2010up clinic population"],"prefix":"10.1111","volume":"51","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2502-1206","authenticated-orcid":false,"given":"Kyung A","family":"Kang","sequence":"first","affiliation":[{"name":"Department of Ra<?oxy_insert_start?><?oxy_insert_end?><?oxy_insert_start?><?oxy_insert_end?>diology Kangbuk Samsung Hospital Sungkyunkwan University School of Medicine Seoul 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