{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T02:16:39Z","timestamp":1791252999961,"version":"4.1.0"},"reference-count":62,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2020,4,22]],"date-time":"2020-04-22T00:00:00Z","timestamp":1587513600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100009332","name":"Mag-TarmFonden, Swedish Gastroenterology Society","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100009332","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007687","name":"Svenska L\u00e4kares\u00e4llskapet","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100007687","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100009332","name":"Mag-TarmFonden, Swedish Gastroenterology Society","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100009332","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Aliment Pharmacol Ther"],"published-print":{"date-parts":[[2020,6]]},"abstract":"<jats:title>Summary<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The vagus nerve provides essential parasympathetic innervation to the gastrointestinal system and is known to have anti\u2010inflammatory properties.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aims<\/jats:title><jats:p>To explore the relationship between vagotomy and the risk of inflammatory bowel disease (IBD) and its major categories: Crohn's disease (CD) and ulcerative colitis (UC).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A matched cohort comprising 15\u00a0637 patients undergoing vagotomy was identified through the Swedish Patient Register from 1964 to 2010. Each vagotomised patient was matched for birth year and gender with 40 nonvagotomised individuals on the date of vagotomy. We estimated hazard ratios (HRs) and 95% confidence intervals (CIs) for IBD using flexible parametric models adjusted for matching variables, year of vagotomy, birth country, chronic obstructive pulmonary disease and comorbidity index.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>We observed 119 (0.8%) patients with vagotomy developed IBD compared to 3377 (0.5%) IBD cases in nonvagotomised individuals. The crude incidence of IBD (per 1000 person\u2010years) was 0.38 for vagotomised patients and 0.25 for nonvagotomised individuals. We observed a time\u2010dependent elevated risk of IBD associated with vagotomy, for instance, the HR (95% CI) was 1.80 (1.40\u20102.31) at year 5 and 1.49 (1.14\u20101.96) at year 10 post\u2010vagotomy. The association appeared to be stronger for truncal than selective vagotomy and limited to CD (HR was 3.63 [1.94\u20106.80] for truncal and 2.06 [1.49\u20102.84] for selective vagotomy) but not UC (1.36 [0.71\u20102.62] for truncal and 1.25 [0.95\u20101.63] for selective vagotomy).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>We found a positive association between vagotomy and later IBD, particularly for CD. The finding indirectly underlines the beneficial role of the vagal tone in IBD.<\/jats:p><\/jats:sec>","DOI":"10.1111\/apt.15715","type":"journal-article","created":{"date-parts":[[2020,4,22]],"date-time":"2020-04-22T07:15:45Z","timestamp":1587539745000},"page":"1022-1030","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":42,"title":["Vagotomy and subsequent risk of inflammatory bowel disease: a nationwide register\u2010based matched cohort study"],"prefix":"10.1111","volume":"51","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0366-6989","authenticated-orcid":false,"given":"Bojing","family":"Liu","sequence":"first","affiliation":[{"name":"Department of Medical Epidemiology and Biostatistics Karolinska Institutet Stockholm Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alkwin","family":"Wanders","sequence":"additional","affiliation":[{"name":"Department of Medical Biosciences Ume\u00e5 University 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