{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T13:48:24Z","timestamp":1791899304541,"version":"4.3.4"},"reference-count":49,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2020,5,3]],"date-time":"2020-05-03T00:00:00Z","timestamp":1588464000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["No.31601404"],"award-info":[{"award-number":["No.31601404"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Aliment Pharmacol Ther"],"published-print":{"date-parts":[[2020,6]]},"abstract":"<jats:title>Summary<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Epidemiological data of coeliac disease are lacking from the central Asian region.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aims<\/jats:title><jats:p>To verify the occurrence of coeliac disease amongst four major ethnic groups of Xinjiang Uyghur Autonomus Region, China.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>2277 in\u2010patients with gastrointestinal symptoms (1391 Han, 608 Uyghur, 146 Kazakh and 132 Hui; mean age: 54\u00a0\u00b1\u00a012.8\u00a0years) were included. Total IgA, anti\u2010deamidated gliadin peptide (DGP)\u2010IgG, and anti\u2010tissue transglutaminase (anti\u2010tTG)\u2010IgA were analysed. All antibody\u2010positive subjects were further tested for endomysial (EMA) antibodies and were HLA genotyped. All subjects with antibody positivity were asked to undergo intestinal biopsy. In addition, a subset of antibody\u2010negative subjects were tested for HLA\u2010DQA1and DQB1.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Among the 2277 subjects, 29 subjects were defined as coeliac disease autoimmune (positive results for anti\u2010tTG IgA and EMA\u2010IgA) (1.27%; 95% confidence interval, 0.81%\u20101.73%), eight of them underwent biopsy and all showed coeliac disease histology (0.35%; 95% Cl, 0.11%\u20100.59%). The frequency of coeliac disease autoimmunity was lowest among the Han (0.79%), followed by the Uyghur (1.81%), the Kazakh (2.05%) and the Hui (3.03%). The frequency of the HLA\u2010DQ2 and\/or DQ8 haplotype was highest in the Uyghur (52.1%), followed by the Hui (44.4%), the Kazakh (40.0%) and the Han (39.4%). Besides, a three times higher frequency of coeliac disease autoimmunity was found among rural living subjects with significantly higher wheat consumption compared to urban living subjects (3.16% vs 0.97%, <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.01).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>In Xinjiang, coeliac disease does occur, especially in the rural area. The HLA haplotype and environment play key roles in the development of coeliac disease.<\/jats:p><\/jats:sec>","DOI":"10.1111\/apt.15737","type":"journal-article","created":{"date-parts":[[2020,5,4]],"date-time":"2020-05-04T03:03:47Z","timestamp":1588561427000},"page":"1116-1129","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":34,"title":["Prevalence of coeliac disease in Northwest China: heterogeneity across Northern Silk road ethnic populations"],"prefix":"10.1111","volume":"51","author":[{"given":"Chunyan","family":"Zhou","sequence":"first","affiliation":[{"name":"State Key Laboratory of Food Science and Technology Nanchang University Nanchang Jiangxi China"},{"name":"School of Food Science and Technology Nanchang University Nanchang Jiangxi China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Feng","family":"Gao","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology People's 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