{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T11:33:52Z","timestamp":1791977632309,"version":"4.4.0"},"reference-count":26,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2020,4,28]],"date-time":"2020-04-28T00:00:00Z","timestamp":1588032000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"name":"Reckitt Benckiser (M) Sdn. Bhd"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Aliment Pharmacol Ther"],"published-print":{"date-parts":[[2020,6]]},"abstract":"<jats:title>Summary<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Late\u2010night supper increases the risk of postprandial reflux from the acid pocket especially in obesity. An alginate\u2010based, raft\u2010forming medication may be useful for obese patients with GERD.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aims<\/jats:title><jats:p>To compare the efficacy of Gaviscon Advance (Reckitt Benckiser, UK) and a non\u2010alginate antacid in post\u2010supper suppression of the acid pocket and post\u2010prandial reflux among obese participants.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Participants underwent 48\u00a0h wireless and probe\u2010based pH\u2010metry recording of the acid pocket and lower oesophagus, respectively, and were randomised to single post\u2010supper (10 <jats:sc>pm<\/jats:sc>) dose of either Gaviscon Advance or a non\u2010alginate antacid on the second night. Primary outcomes were suppression of median pH of acid pocket and lower oesophagus, measured every 10\u2010minutes post\u2010supper for 1\u00a0h. Secondary outcomes were suppression of % time pH\u00a0&lt;\u00a04 at lower oesophagus and improvement in frequency and visual analogue score (VAS) of regurgitation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Of the 81 screened participants, 55 were excluded and 26 (mean age 33.5\u00a0years, males 77.8% and BMI 32.8\u00a0kg\/m<jats:sup>2<\/jats:sup>) were randomised to Gaviscon Advance (n\u00a0=\u00a013) or antacid (n\u00a0=\u00a013). Median pH of the acid pocket but not the lower oesophagus was suppressed with Gaviscon Advance vs antacid (all <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.04) Gaviscon Advance but not antacid significantly reduced in % time pH\u00a0&lt;\u00a04, symptom frequency and VAS on day 2 vs day 1 (all <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.05).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Among obese individuals, Gaviscon Advance was superior to a non\u2010alginate antacid in post\u2010supper suppression of the acid pocket. (Clinical trial registration unique identifier: NCT03516188).<\/jats:p><\/jats:sec>","DOI":"10.1111\/apt.15746","type":"journal-article","created":{"date-parts":[[2020,4,28]],"date-time":"2020-04-28T12:19:01Z","timestamp":1588076341000},"page":"1014-1021","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["Randomised clinical trial: the effectiveness of Gaviscon Advance vs non\u2010alginate antacid in suppression of acid pocket and post\u2010prandial reflux in obese individuals after late\u2010night supper"],"prefix":"10.1111","volume":"51","author":[{"given":"Mohd Adli","family":"Deraman","sequence":"first","affiliation":[{"name":"School of Medical Sciences Universiti Sains Malaysia Kota Bahru Malaysia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Muhammad Ilham","family":"Abdul Hafidz","sequence":"additional","affiliation":[{"name":"Faculty of Medicine Universiti Teknologi MARA Sungai Buloh 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