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We linked data to Cancer and Causes of Death Registers and examined the absolute and relative risks of pancreatic cancer and pancreatic cancer death.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Among 161\u00a0926 patients followed for 2\u00a0000\u00a0951 person years, 442 (0.27%) were diagnosed with pancreatic cancer compared to 3386 (0.21%) of the 1\u00a0599\u00a0024 reference individuals. The 20\u2010year cumulative incidence was 0.34% (95% confidence interval 0.30\u20100.38) vs 0.29% (0.28\u20100.30). The incidence rate was 22.1 (20.1\u201024.2)\/100\u00a0000 person years in the patients (excluding the first year of follow\u2010up: 20.8 [18.8\u201023.0]), and 16.6 (16.0\u201017.2) in the reference individuals. The hazard ratio (HR) for pancreatic cancer was increased overall: 1.43 (1.30\u20101.58), in subtypes (Crohn's disease: 1.44 [1.18\u20101.74]; ulcerative colitis: 1.35 [1.19\u20101.53]; IBD unclassified: 1.99 [1.50\u20102.64]) and especially in IBD patients with primary sclerosing cholangitis: 7.55 (4.94\u201011.5). Patients and reference individuals with pancreatic cancer did not differ in cancer stage (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.17) or pancreatic cancer mortality (HR 1.07 [0.95\u20101.21]).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Patients with IBD had an excess risk of pancreatic cancer, in particular patients with primary sclerosing cholangitis. However, the cumulative incidence difference after 20\u00a0years was small: 0.05%, that is, one extra pancreatic cancer per 2000 IBD patients.<\/jats:p><\/jats:sec>","DOI":"10.1111\/apt.15785","type":"journal-article","created":{"date-parts":[[2020,5,16]],"date-time":"2020-05-16T00:55:46Z","timestamp":1589590546000},"page":"143-154","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":41,"title":["Inflammatory bowel disease and pancreatic cancer: a Scandinavian register\u2010based cohort study 1969\u20102017"],"prefix":"10.1111","volume":"52","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0311-8894","authenticated-orcid":false,"given":"\u00c5sa H.","family":"Everhov","sequence":"first","affiliation":[{"name":"Stockholm Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9398-9185","authenticated-orcid":false,"given":"Rune","family":"Erichsen","sequence":"additional","affiliation":[{"name":"Aarhus Denmark"},{"name":"Randers Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael C.","family":"Sachs","sequence":"additional","affiliation":[{"name":"Stockholm Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lars","family":"Pedersen","sequence":"additional","affiliation":[{"name":"Aarhus Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonas","family":"Halfvarson","sequence":"additional","affiliation":[{"name":"\u00d6rebro Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johan","family":"Askling","sequence":"additional","affiliation":[{"name":"Stockholm Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anders","family":"Ekbom","sequence":"additional","affiliation":[{"name":"Stockholm Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1024-5602","authenticated-orcid":false,"given":"Jonas F.","family":"Ludvigsson","sequence":"additional","affiliation":[{"name":"Stockholm Sweden"},{"name":"\u00d6rebro Sweden"},{"name":"Nottingham UK"},{"name":"New York City NY USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Henrik Toft","family":"S\u00f8rensen","sequence":"additional","affiliation":[{"name":"Aarhus Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ola","family":"Ol\u00e9n","sequence":"additional","affiliation":[{"name":"Stockholm Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,5,15]]},"reference":[{"key":"e_1_2_9_2_1","unstructured":"World Health Organization.GLOBOCAN 2018 Pancreas 2019. http:\/\/gco.iarc.fr\/today\/data\/factsheets\/cancers\/13\u2010Pancreas\u2010fact\u2010sheet.pdf. 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