{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T17:52:01Z","timestamp":1790099521235,"version":"4.0.1"},"reference-count":51,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2020,6,7]],"date-time":"2020-06-07T00:00:00Z","timestamp":1591488000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"name":"Deutsche Leberstiftung"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Aliment Pharmacol Ther"],"published-print":{"date-parts":[[2020,7]]},"abstract":"<jats:title>Summary<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>To evaluate medical versus interventional treatment (transjugular thrombus fragmentation, local thrombolysis with or without stent implantation) in patients with acute non\u2010cirrhotic, non\u2010malignant portal vein thrombosis (PVT).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This prospective, observational study enrolled 65 patients with acute (&lt;28\u00a0days since begin of symptoms, no cavernoma) PVT in nine centres. Thirty patients received medical treatment and 35 patients received interventional treatment. PVT was graded into grade 1: short thrombosis and incomplete occlusion of the vessel lumen and grade 2: extended thrombosis or complete occlusion. Treatment response was classified as partial or complete, if thrombosis was reduced by one grade or to &lt;25% of the vessel diameter respectively.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Partial and complete response rates were 7% and 30% in the medical compared to 17% and 54% (\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0&lt;\u00a00.001) in the interventional treatment group. In the multivariate analysis, interventional treatment showed a strong positive (OR 4.32,\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0&lt;\u00a00.016) and a myeloproliferative aetiology a negative (OR 0.09,\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0=\u00a00.006) prediction of complete response. Complications were rare in the medical group and consisted of septicaemia and upper gastrointestinal bleeding of unknown origin in one patient each. Interventional treatment was accompanied by mild and self\u2010limiting bleeding complications in nine patients, moderate intra\u2010abdominal bleeding requiring transfusions (2 units) in one patient and peritoneal bleeding requiring surgical rescue in one patient. Four patients in each group developed intestinal gangrene requiring surgery. One patient died 52\u00a0days after unsuccessful interventional treatment.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Compared to medical treatment alone, interventional treatment doubled response rates at the cost of increased bleeding complications.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/apt.15811","type":"journal-article","created":{"date-parts":[[2020,6,7]],"date-time":"2020-06-07T10:12:23Z","timestamp":1591524743000},"page":"329-339","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":55,"title":["A prospective, multicentre study in acute non\u2010cirrhotic, non\u2010malignant portal vein thrombosis: comparison of medical and interventional 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