{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,2]],"date-time":"2026-04-02T16:57:20Z","timestamp":1775149040131,"version":"3.50.1"},"reference-count":77,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2020,6,2]],"date-time":"2020-06-02T00:00:00Z","timestamp":1591056000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Aliment Pharmacol Ther"],"published-print":{"date-parts":[[2020,7]]},"abstract":"<jats:title>Summary<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Severe acute respiratory syndrome coronavirus 2 (SARS\u2010CoV\u20102), the causative pathogen of coronavirus disease 2019 (COVID\u201019), became a global threat to human health. Liver impairment has been frequently reported as a common manifestation, although its clinical significance is still unclear, particularly in patients with underlying chronic liver disease (CLD).<\/jats:p><\/jats:sec><jats:sec><jats:title>Aims<\/jats:title><jats:p>To summarise the changes in liver function tests during SARS\u2010CoV\u20102 infection and the impact of COVID\u201019 in patients with underlying CLD.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A literature review using online database PubMed was done using the search terms \u201cSARS\u2010CoV\u20102\u201d, \u201cCOVID\u201019\u201d, \u201cliver\u201d, \u201ccirrhosis\u201d and \u201cliver transplantation\u201d.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>COVID\u201019 is frequently associated with different degrees of abnormal liver function tests, most notably transaminases, which are usually transitory and of mild degree. Available evidence suggests that liver injury may result from direct pathogenic effect by the virus, systemic inflammation or toxicity from commonly used drugs in this subset of patients. SARS\u2010CoV\u20102 infection in children is associated with minimal or no increase in liver enzymes, thus the presence of abnormal liver function tests should trigger evaluation for underlying liver diseases. Although it seems that patients with CLD are not at greater risk for acquiring the infection, those with cirrhosis, hepatocellular carcinoma, non\u2010alcoholic fatty liver disease, autoimmune liver diseases or liver transplant may have a greater risk for severe COVID\u201019.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Abnormal liver function tests during the course of COVID\u201019 are common, though clinically significant liver injury is rare. Further research is needed focusing on the effect of existing liver\u2010related comorbidities on treatment and outcome of COVID\u201019.<\/jats:p><\/jats:sec>","DOI":"10.1111\/apt.15813","type":"journal-article","created":{"date-parts":[[2020,5,14]],"date-time":"2020-05-14T00:18:04Z","timestamp":1589415484000},"page":"267-275","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":143,"title":["Review article: COVID\u201019 and liver disease\u2014what we know on 1st May 2020"],"prefix":"10.1111","volume":"52","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7801-466X","authenticated-orcid":false,"given":"Isabel","family":"Garrido","sequence":"first","affiliation":[{"name":"Gastroenterology and Hepatology Department Centro Hospitalar Sao Joao Porto Portugal"},{"name":"World Gastroenterology Organization (WGO) Porto Training Center Porto 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