{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,5]],"date-time":"2026-03-05T17:12:07Z","timestamp":1772730727493,"version":"3.50.1"},"reference-count":44,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2020,6,11]],"date-time":"2020-06-11T00:00:00Z","timestamp":1591833600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Aliment Pharmacol Ther"],"published-print":{"date-parts":[[2020,7]]},"abstract":"<jats:title>Summary<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Crohn's disease (CD) and hidradenitis suppurativa (HS), a chronic inflammatory skin disease, induce similar inflammatory lesions of the groin and gluteal area. Both diseases are characterised by an inadequate immune response to commensal bacteria in genetically predisposed subjects and can be associated.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aim<\/jats:title><jats:p>To assess whether HS was associated with clinical and prognostic factors in CD.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A retrospective case\u2010control study included 4645 patients with CD referred to Saint\u2010Antoine Hospital gastroenterology tertiary care centre between 2003 and 2016. Matching variables were sex, age, age and the presence of perianal lesions at CD diagnosis, follow\u2010up quality. HS was confirmed by dermatological examination; location, phenotype and severity (Hurley staging) were recorded.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Hidradenitis suppurativa prevalence was 0.95% (44 cases); 80% of patients displayed Hurley stage II or III disease. CD preceded HS in 70% of cases with a median interval of 9\u00a0years (IQR 5.25\u201012.75). CD with HS was more active (56% vs 40% years with active disease, <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.001) and required more anti\u2010TNF agents (39% vs 23% years spent with anti\u2010TNF treatment, <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.001) than CD without HS. HS was associated with a higher risk of permanent stoma, 16.8% (IQR 7.5\u201033.3) vs 2.5% (IQR 0.8\u20107.4) in the control group (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.002). Multivariate analysis confirmed HS as independent risk factor for permanent stoma (odds ratio 6.19; 95% CI, 2.30\u201038.33; <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.001).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Hidradenitis suppurativa is associated with worse CD prognosis, more active disease and increased risk of permanent stoma, despite a higher use of anti\u2010TNF agents.<\/jats:p><\/jats:sec>","DOI":"10.1111\/apt.15863","type":"journal-article","created":{"date-parts":[[2020,6,11]],"date-time":"2020-06-11T13:24:45Z","timestamp":1591881885000},"page":"303-310","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Increased risk of permanent stoma in Crohn\u2019s disease associated with hidradenitis suppurativa: a case\u2010control study"],"prefix":"10.1111","volume":"52","author":[{"given":"Louis\u2010Marie","family":"Dumont","sequence":"first","affiliation":[{"name":"Department of Gastroenterology Saint\u2010Antoine Hospital AP\u2010HP Paris France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C\u00e9cilia","family":"Landman","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Saint\u2010Antoine Hospital AP\u2010HP Paris France"},{"name":"Sorbonne University Paris France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2914-1822","authenticated-orcid":false,"given":"Harry","family":"Sokol","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Saint\u2010Antoine Hospital AP\u2010HP Paris France"},{"name":"Sorbonne University Paris France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laurent","family":"Beaugerie","sequence":"additional","affiliation":[{"name":"Department of 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