{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T18:34:53Z","timestamp":1791484493107,"version":"4.3.4"},"reference-count":21,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2020,7,23]],"date-time":"2020-07-23T00:00:00Z","timestamp":1595462400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"name":"HK inno.N Corp."}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Aliment Pharmacol Ther"],"published-print":{"date-parts":[[2020,9]]},"abstract":"<jats:title>Summary<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Tegoprazan is a novel potassium\u2010competitive acid blocker for the treatment of acid\u2010related disorders.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aims<\/jats:title><jats:p>To assess whether tegoprazan is non\u2010inferior to lansoprazole in terms of efficacy and safety in patients with gastric ulcers.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>In this phase 3, double\u2010blind, active control, multicentre study, 306 gastric ulcer patients were randomised to one of three treatment groups: tegoprazan 50\u00a0mg, tegoprazan 100\u00a0mg and lansoprazole 30\u00a0mg once daily for 4 or 8\u00a0weeks. The primary endpoint was the cumulative proportion of patients with healed ulcers confirmed by endoscopy up to 8\u00a0weeks from treatment initiation. Symptoms and safety were assessed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In the full analysis set, the cumulative healing rates at week 8 were 94.8% (91\/96) for the tegoprazan 50\u00a0mg, 95.0% (94\/99) for the tegoprazan 100\u00a0mg and 95.7% (89\/93) for the lansoprazole 30\u00a0mg groups. At week 4, the respective healing rates were 90.6% (87\/96), 91.9% (91\/99), and 89.2% (83\/93). In per protocol analysis, 4\u2010week healing rates were 95.4% (84\/88), 94.6% (88\/93) and 92.9% (79\/85) for tegoprazan 50\u00a0mg, tegoprazan 100\u00a0mg and lansoprazole 30\u00a0mg, respectively. Both doses of tegoprazan were non\u2010inferior to lansoprazole in ulcer healing at 4 and 8\u00a0weeks. The incidence of drug\u2010related treatment\u2010emergent adverse events did not differ among groups. The increase in serum gastrin concentration was not higher in tegoprazan\u2010treated patients than in lansoprazole\u2010treated patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Tegoprazan 50 or 100\u00a0mg were not inferior to lansoprazole 30\u00a0mg once daily in the treatment of gastric ulcers.<\/jats:p><\/jats:sec>","DOI":"10.1111\/apt.15865","type":"journal-article","created":{"date-parts":[[2020,7,23]],"date-time":"2020-07-23T15:10:55Z","timestamp":1595517055000},"page":"789-797","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":87,"title":["Randomised clinical trial: tegoprazan, a novel potassium\u2010competitive acid blocker, or lansoprazole in the treatment of gastric ulcer"],"prefix":"10.1111","volume":"52","author":[{"given":"Yu Kyung","family":"Cho","sequence":"first","affiliation":[{"name":"Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7297-6577","authenticated-orcid":false,"given":"Myung\u2010Gyu","family":"Choi","sequence":"additional","affiliation":[{"name":"Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suck Chei","family":"Choi","sequence":"additional","affiliation":[{"name":"Iksan Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kee Myung","family":"Lee","sequence":"additional","affiliation":[{"name":"Suwon Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tae Oh","family":"Kim","sequence":"additional","affiliation":[{"name":"Busan Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Soo\u2010Heon","family":"Park","sequence":"additional","affiliation":[{"name":"Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeong Seop","family":"Moon","sequence":"additional","affiliation":[{"name":"Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yun Jeong","family":"Lim","sequence":"additional","affiliation":[{"name":"Goyang Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dae Hwan","family":"Kang","sequence":"additional","affiliation":[{"name":"Yangsan Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gab Jin","family":"Cheon","sequence":"additional","affiliation":[{"name":"Gangneung Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gwang Ho","family":"Baik","sequence":"additional","affiliation":[{"name":"Chuncheon Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kyoung Oh","family":"Kim","sequence":"additional","affiliation":[{"name":"Incheon Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kwang Bum","family":"Cho","sequence":"additional","affiliation":[{"name":"Daegu Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jin Seok","family":"Jang","sequence":"additional","affiliation":[{"name":"Busan Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jong\u2010Jae","family":"Park","sequence":"additional","affiliation":[{"name":"Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Byoung Kwan","family":"Son","sequence":"additional","affiliation":[{"name":"Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6653-5214","authenticated-orcid":false,"given":"Hye\u2010Kyung","family":"Jung","sequence":"additional","affiliation":[{"name":"Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2290-4954","authenticated-orcid":false,"given":"Byung\u2010Wook","family":"Kim","sequence":"additional","affiliation":[{"name":"Incheon Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sung Kuk","family":"Kim","sequence":"additional","affiliation":[{"name":"Daegu Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Soo Teik","family":"Lee","sequence":"additional","affiliation":[{"name":"Jeonju Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jae Myung","family":"Cha","sequence":"additional","affiliation":[{"name":"Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ah Rong","family":"Kim","sequence":"additional","affiliation":[{"name":"Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eun Ji","family":"Kim","sequence":"additional","affiliation":[{"name":"Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hyun Wook","family":"Park","sequence":"additional","affiliation":[{"name":"Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Geun Seog","family":"Song","sequence":"additional","affiliation":[{"name":"Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,7,23]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02214870"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1053\/bega.2001.0184"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.5056\/jnm.2013.19.1.25"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.5009\/gnl15502"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.5056\/jnm18029"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.5056\/jnm18139"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bcp.2011.02.009"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40262-015-0326-7"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/apt.14130"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/apt.13461"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1177\/0300060519828514"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/apt.13876"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/1751-2980.12813"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1124\/jpet.117.244202"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/apt.15438"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/apt.15480"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1124\/jpet.118.254904"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/apt.15185"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2008.11.021"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2036.2009.04124.x"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2008.05.021"}],"container-title":["Alimentary Pharmacology &amp; Therapeutics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fapt.15865","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/apt.15865","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,5]],"date-time":"2023-09-05T20:37:23Z","timestamp":1693946243000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/apt.15865"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,7,23]]},"references-count":21,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2020,9]]}},"alternative-id":["10.1111\/apt.15865"],"URL":"https:\/\/doi.org\/10.1111\/apt.15865","archive":["Portico"],"relation":{},"ISSN":["0269-2813","1365-2036"],"issn-type":[{"value":"0269-2813","type":"print"},{"value":"1365-2036","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,7,23]]},"assertion":[{"value":"2020-03-11","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-05-15","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-07-23","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}