{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,11]],"date-time":"2026-04-11T04:19:43Z","timestamp":1775881183207,"version":"3.50.1"},"reference-count":43,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2020,8,4]],"date-time":"2020-08-04T00:00:00Z","timestamp":1596499200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Aliment Pharmacol Ther"],"published-print":{"date-parts":[[2020,9]]},"abstract":"<jats:title>Summary<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Food antigens are clearly implicated in the induction and persistence of eosinophilic oesophagitis. Dietary elimination to identify triggers is tedious and expensive. Alternatives that can mitigate cost and improve patient quality of life during this process are needed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aims<\/jats:title><jats:p>To test the hypothesis that antibodies against foods that trigger eosinophilic oesophagitis are secreted into the oesophageal lumen where they can be collected by oesophageal brushings.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We evaluated food\u2010specific immune responses within brushings in 68 patients undergoing endoscopy (12 controls, 13 resolved eosinophilic oesophagitis and 43 active eosinophilic oesophagitis). Seventeen participants identified their trigger foods via food elimination diets. Immunoglobulin A and immunoglobulin G4 antibodies against the four most common eosinophilic oesophagitis food triggers were measured using the ImmunoCAP assay in the oesophageal brushings. Food\u2010specific antibody values were compared between active eosinophilic oesophagitis, resolved eosinophilic oesophagitis and controls.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Patients with active eosinophilic oesophagitis (&gt;15 eosinophils\/hpf) demonstrated increased immunoglobulin A and immunoglobulin G4 levels to common eosinophilic oesophagitis triggers compared to controls (327\u00a0\u00b1\u00a0380 vs 150\u00a0\u00b1\u00a0130 for immunoglobulin A, and 1534\u00a0\u00b1\u00a03346 vs 178\u00a0\u00b1\u00a0123 for immunoglobulin G4, <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.003). Specific trigger foods were associated with elevated immunoglobulin A and immunoglobulin G4 responses compared to foods that did not trigger oesophageal eosinophilia (733\u00a0\u00b1\u00a0469 vs 142\u00a0\u00b1\u00a064, <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.001 immunoglobulin A and 2620\u00a0\u00b1\u00a03228 vs 526\u00a0\u00b1\u00a01050, <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.001 immunoglobulin G4).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Food\u2010specific antibodies are easily collected along the oesophageal lumen of eosinophilic oesophagitis patients. Further studies are needed to validate our preliminary findings to determine whether these antibodies can be used to guide elimination diet therapy.<\/jats:p><\/jats:sec>","DOI":"10.1111\/apt.15879","type":"journal-article","created":{"date-parts":[[2020,8,4]],"date-time":"2020-08-04T15:13:25Z","timestamp":1596554005000},"page":"997-1007","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["Food\u2010specific antibodies in oesophageal secretions: association with trigger foods in eosinophilic oesophagitis"],"prefix":"10.1111","volume":"52","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1793-6027","authenticated-orcid":false,"given":"Kathryn","family":"Peterson","sequence":"first","affiliation":[{"name":"Division of Gastroenterology University of Utah Salt Lake City UT USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Edwin","family":"Lin","sequence":"additional","affiliation":[{"name":"Department 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Clinic Salt Lake City UT USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jacob","family":"Robson","sequence":"additional","affiliation":[{"name":"Division of Pediatric Gastroenterology University of Utah Salt Lake City UT USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gerald","family":"Gleich","sequence":"additional","affiliation":[{"name":"Division of Allergy Department of Dermatology University of Utah Salt Lake City UT 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