{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,5]],"date-time":"2026-11-05T04:29:10Z","timestamp":1793852950702,"version":"4.6.1"},"reference-count":31,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2020,7,3]],"date-time":"2020-07-03T00:00:00Z","timestamp":1593734400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000062","name":"National Institute of Diabetes and Digestive and Kidney Diseases","doi-asserted-by":"publisher","award":["R03 DK113337"],"award-info":[{"award-number":["R03 DK113337"]}],"id":[{"id":"10.13039\/100000062","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100004319","name":"Pfizer","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004319","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Aliment Pharmacol Ther"],"published-print":{"date-parts":[[2020,8]]},"abstract":"<jats:title>Summary<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>There are limited data on population\u2010wide assessment of cost in Crohn's disease (CD) and ulcerative colitis (UC).<\/jats:p><\/jats:sec><jats:sec><jats:title>Aim<\/jats:title><jats:p>To estimate the societal cost of actively treated CD and UC in Sweden.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We identified 10\u00a0117 prevalent CD and 19\u00a0762 prevalent UC patients, aged \u226518\u00a0years on 1 January 2014 and 4028 adult incident CD cases and 8659 adult incident UC cases (2010\u20102013) from Swedish Patient Register. Each case was matched to five population comparators. Healthcare costs were calculated from medications, outpatient visits, hospitalisations and surgery. Cost of productivity losses was derived from disability pension and sick leave.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The mean annual societal costs per working\u2010age patient (18\u201064\u00a0years) with CD and UC were $22\u00a0813 (vs $7533 per comparator) and $14\u00a0136 (vs $7351 per comparator), respectively. In patients aged \u226565\u00a0years, the mean annual costs of CD and UC were $9726 and $8072 vs $3875 and $4016 per comparator, respectively. The majority of cost for both CD (56%) and UC (59%) patients originated from productivity losses. Higher societal cost of working\u2010age CD patients as compared to UC patients was related to greater utilisation of anti\u2010TNF (22.2% vs 7.4%) and increased annual disability pension (44\u00a0days vs 25\u00a0days). Among incident CD and UC patients, the mean total cost over the first year per patient was over three times higher than comparators.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>In Sweden, the societal cost of incident and prevalent CD and UC patients was consistently two to three times higher than the general population.<\/jats:p><\/jats:sec>","DOI":"10.1111\/apt.15889","type":"journal-article","created":{"date-parts":[[2020,7,4]],"date-time":"2020-07-04T05:44:30Z","timestamp":1593841470000},"page":"655-668","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":58,"title":["Healthcare use, work loss and total costs in incident and prevalent Crohn's disease and ulcerative colitis: results from a nationwide study in Sweden"],"prefix":"10.1111","volume":"52","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7956-6941","authenticated-orcid":false,"given":"Hamed","family":"Khalili","sequence":"first","affiliation":[{"name":"Boston MA USA"},{"name":"Stockholm Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0311-8894","authenticated-orcid":false,"given":"\u00c5sa H.","family":"Everhov","sequence":"additional","affiliation":[{"name":"Stockholm Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonas","family":"Halfvarson","sequence":"additional","affiliation":[{"name":"\u00d6rebro Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1024-5602","authenticated-orcid":false,"given":"Jonas F.","family":"Ludvigsson","sequence":"additional","affiliation":[{"name":"Stockholm Sweden"},{"name":"\u00d6rebro 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