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Therefore, it is important to understand how new therapies for non\u2010alcoholic steatohepatitis (NASH) may impact CVD risk factors in these patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aims<\/jats:title><jats:p>To summarise the effects of drug therapies on lipid and lipoprotein levels in patients with NASH and provide insight into the potential mechanisms for the observed changes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>PubMed searches of the literature were performed and results were compiled.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Recent clinical trials have highlighted the safety and efficacy of drug candidates for the treatment of NASH. Several agents have shown improvements in the histological features of NASH and liver function. Pioglitazone, a drug that is currently available for type 2 diabetes and may be useful for NASH, exhibits beneficial effects on lipids. However, agents such as farnesoid X receptor agonists, which are in development for NASH, may adversely affect circulating lipids and lipoproteins.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>NASH is a multi\u2010system disease with a disproportionate CVD burden. Current and future drugs for NASH have had variable impact on the atherogenic risk profile. Potential co\u2010administration of a statin may help mitigate the negative impact of some of these therapies on lipid and lipoprotein levels.<\/jats:p><\/jats:sec>","DOI":"10.1111\/apt.15935","type":"journal-article","created":{"date-parts":[[2020,7,8]],"date-time":"2020-07-08T08:10:15Z","timestamp":1594195815000},"page":"619-636","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Review article: the impact of liver\u2010directed therapies on the atherogenic risk profile in non\u2010alcoholic steatohepatitis"],"prefix":"10.1111","volume":"52","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3917-592X","authenticated-orcid":false,"given":"Margery A.","family":"Connelly","sequence":"first","affiliation":[{"name":"Laboratory Corporation of America Holdings (LabCorp) Morrisville NC USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jonathan","family":"Velez 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