{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T22:30:20Z","timestamp":1790116220203,"version":"4.0.1"},"reference-count":26,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2020,8,8]],"date-time":"2020-08-08T00:00:00Z","timestamp":1596844800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Aliment Pharmacol Ther"],"published-print":{"date-parts":[[2020,9]]},"abstract":"<jats:title>Summary<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Data on the long\u2010term administration of ustekinumab in recommended doses are limited.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aim<\/jats:title><jats:p>To assess the real\u2010world, long\u2010term effectiveness of ustekinumab in refractory Crohn's disease (CD).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Multi\u2010centre study of CD patients starting ustekinumab at the recommended dose, followed for 1\u00a0year. Values for the Harvey\u2010Bradshaw Index (HBI), endoscopic activity, C\u2010reactive protein (CRP), and faecal calprotectin (FC) were recorded at baseline and at weeks 26 and 52. Demographic and clinical data, previous treatments, adverse events (AEs) and hospitalisations were documented. Potential predictors of remission were examined.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 407 patients were analysed. The initial maintenance dose of 90\u00a0mg SC was administered every 12, 8 and 4\u00a0weeks in 56 (14%), 347 (85%) and 4 (1%) patients, respectively. After 52\u00a0weeks, treatment was discontinued in 112 patients (27.5%). At baseline, 295 (72%) had an HBI &gt;4 points. Of these, 169 (57%) and 190 (64%) achieved clinical remission at weeks 26 and 52, respectively. FC levels returned to normal in 44% and 54% of patients at weeks 26 and 52, and CRP returned to normal in 36% and 37% of patients at weeks 26 and 52, respectively. AEs were recorded in 60 patients. The use of fewer previous anti\u2010TNF\u03b1 agents and ileal localisation were associated with clinical remission, and endoscopic severity was associated with poor response. No factors correlated with endoscopic remission.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>After 52 weeks, ustekinumab demonstrated effectiveness in inducing clinical and endoscopic remission in patients with refractory CD.<\/jats:p><\/jats:sec>","DOI":"10.1111\/apt.15958","type":"journal-article","created":{"date-parts":[[2020,8,8]],"date-time":"2020-08-08T17:00:41Z","timestamp":1596906041000},"page":"1017-1030","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":64,"title":["Real\u2010world long\u2010term effectiveness of ustekinumab in Crohn's disease: results from the ENEIDA registry"],"prefix":"10.1111","volume":"52","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7360-7581","authenticated-orcid":false,"given":"Marisa","family":"Iborra","sequence":"first","affiliation":[{"name":"Valencia Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bel\u00e9n","family":"Beltr\u00e1n","sequence":"additional","affiliation":[{"name":"Valencia Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Agnes","family":"Fern\u00e1ndez\u2010Clotet","sequence":"additional","affiliation":[{"name":"Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eva","family":"Iglesias\u2010Flores","sequence":"additional","affiliation":[{"name":"C\u00f3rdoba Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pablo","family":"Navarro","sequence":"additional","affiliation":[{"name":"Valencia Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Montserrat","family":"Rivero","sequence":"additional","affiliation":[{"name":"Santander Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana","family":"Guti\u00e9rrez","sequence":"additional","affiliation":[{"name":"Alicante Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M\u00f3nica","family":"Sierra\u2010Ausin","sequence":"additional","affiliation":[{"name":"Le\u00f3n Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francisco","family":"Mesonero","sequence":"additional","affiliation":[{"name":"Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roc\u00edo","family":"Ferreiro\u2010Iglesias","sequence":"additional","affiliation":[{"name":"Santiago de Compostela Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2157-9328","authenticated-orcid":false,"given":"Joaqu\u00edn","family":"Hinojosa","sequence":"additional","affiliation":[{"name":"Valencia Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xavier","family":"Calvet","sequence":"additional","affiliation":[{"name":"Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Beatriz","family":"Sicilia","sequence":"additional","affiliation":[{"name":"Burgos Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlos","family":"Gonz\u00e1lez\u2010Mu\u00f1oza","sequence":"additional","affiliation":[{"name":"Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Beatriz","family":"Antol\u00edn","sequence":"additional","affiliation":[{"name":"Valladolid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mar\u00eda","family":"Gonz\u00e1lez\u2010Vivo","sequence":"additional","affiliation":[{"name":"Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana Y.","family":"Carbajo","sequence":"additional","affiliation":[{"name":"Valladolid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Santiago","family":"Garc\u00eda\u2010L\u00f3pez","sequence":"additional","affiliation":[{"name":"Zaragoza Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7090-0106","authenticated-orcid":false,"given":"Albert","family":"Mart\u00edn\u2010Cardona","sequence":"additional","affiliation":[{"name":"Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gerard","family":"Sur\u00eds","sequence":"additional","affiliation":[{"name":"Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mar\u00eda Dolores","family":"Martin\u2010Arranz","sequence":"additional","affiliation":[{"name":"Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruth","family":"de Francisco","sequence":"additional","affiliation":[{"name":"Asturias Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fiorella","family":"Ca\u00f1ete","sequence":"additional","affiliation":[{"name":"Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2315-7196","authenticated-orcid":false,"given":"Eugeni","family":"Dom\u00e8nech","sequence":"additional","affiliation":[{"name":"Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pilar","family":"Nos","sequence":"additional","affiliation":[{"name":"Valencia Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"GETECCU group (Grupo Espa\u00f1ol de trabajo de Enfermedades de Crohn y Colitis Ulcerosa)","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,8,8]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1177\/2040622316653306"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.2147\/DDDT.S102141"},{"key":"e_1_2_7_4_1","first-page":"173","article-title":"Profile of ustekinumab and its potential in patients with moderate\u2010to\u2010severe Crohn's disease","volume":"7","author":"Tuskey A","year":"2014","journal-title":"Clin Exp Gastroenterol"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms18102020"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.4161\/mabs.3.6.17815"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1602773"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/apt.14794"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2018.06.035"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1093\/ecco-jcc\/jjz110"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1093\/ecco-jcc\/jjz119"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1093\/ecco-jcc\/jjz080"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1093\/ecco-jcc\/jjz008"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1080\/00365521.2019.1624817"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.5217\/ir.2019.00012"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v25.i31.4481"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/apt.15371"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1093\/ecco-jcc\/jjw168"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(80)92767-1"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/apt.13083"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2018.01.043"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2017.03.032"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1093\/ecco-jcc\/jjz195"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2018.01.030"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1080\/00365521.2019.1597159"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1111\/apt.14419"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2019.02.044"}],"container-title":["Alimentary Pharmacology &amp; Therapeutics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fapt.15958","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/apt.15958","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,5]],"date-time":"2023-09-05T03:43:21Z","timestamp":1693885401000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/apt.15958"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,8,8]]},"references-count":26,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2020,9]]}},"alternative-id":["10.1111\/apt.15958"],"URL":"https:\/\/doi.org\/10.1111\/apt.15958","archive":["Portico"],"relation":{},"ISSN":["0269-2813","1365-2036"],"issn-type":[{"value":"0269-2813","type":"print"},{"value":"1365-2036","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,8,8]]},"assertion":[{"value":"2020-03-27","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-06-20","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-08-08","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}