{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T17:40:37Z","timestamp":1792172437557,"version":"4.4.0"},"reference-count":52,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2020,7,27]],"date-time":"2020-07-27T00:00:00Z","timestamp":1595808000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100010414","name":"Health Research Board","doi-asserted-by":"publisher","award":["HRA\u2010POR\u20102015\u20101185"],"award-info":[{"award-number":["HRA\u2010POR\u20102015\u20101185"]}],"id":[{"id":"10.13039\/100010414","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Aliment Pharmacol Ther"],"published-print":{"date-parts":[[2020,10]]},"abstract":"<jats:title>Summary<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Lifestyle interventions are the primary treatment for metabolic (dysfunction) associated fatty liver disease (MAFLD). However, the histological and cardiometabolic effects of aerobic exercise in MAFLD remain unclear.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>To assess the effects of a 12\u2010week aerobic exercise intervention on histological and cardiometabolic endpoints in MAFLD.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Patients with biopsy\u2010confirmed MAFLD participated in a 12\u2010week aerobic exercise intervention. Liver histology, cardiorespiratory fitness (estimated V\u0307O\n                      <jats:sub>2max<\/jats:sub>\n                      ), physical activity, anthropometry and biochemical markers were assessed at baseline, intervention completion, and 12 and 52 weeks after intervention completion.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Twenty\u2010four patients completed the exercise intervention (exercise group n\u00a0=\u00a016, control group n\u00a0=\u00a08). In the exercise group, 12 weeks of aerobic exercise reduced fibrosis and hepatocyte ballooning by one stage in 58% (\n                      <jats:italic>P\u00a0<\/jats:italic>\n                      =\u00a00.034) and 67% (\n                      <jats:italic>P\u00a0<\/jats:italic>\n                      =\u00a00.020) of patients, with no changes in steatosis (\n                      <jats:italic>P\u00a0<\/jats:italic>\n                      =\u00a01.000), lobular inflammation (\n                      <jats:italic>P\u00a0<\/jats:italic>\n                      =\n                      <jats:italic>\u00a0<\/jats:italic>\n                      0.739) or NAFLD activity score (\n                      <jats:italic>P\u00a0<\/jats:italic>\n                      =\n                      <jats:italic>\u00a0<\/jats:italic>\n                      0.172). Estimated V\u0307O\n                      <jats:sub>2max<\/jats:sub>\n                      increased by 17% compared to the control group (\n                      <jats:italic>P\u00a0<\/jats:italic>\n                      =\n                      <jats:italic>\u00a0<\/jats:italic>\n                      0.027) but this level of improvement was not maintained at 12 or 52 weeks after the intervention. Patients with fibrosis and ballooning improvement increased estimated V\u0307O\n                      <jats:sub>2max<\/jats:sub>\n                      by 25% (\n                      <jats:italic>P\u00a0<\/jats:italic>\n                      =\n                      <jats:italic>\u00a0<\/jats:italic>\n                      0.020) and 26% (\n                      <jats:italic>P\u00a0<\/jats:italic>\n                      =\n                      <jats:italic>\u00a0<\/jats:italic>\n                      0.010), respectively. Anthropometric reductions including body mass (\n                      <jats:italic>P\u00a0<\/jats:italic>\n                      =\n                      <jats:italic>\u00a0<\/jats:italic>\n                      0.038), waist circumference (\n                      <jats:italic>P\u00a0<\/jats:italic>\n                      =\n                      <jats:italic>\u00a0<\/jats:italic>\n                      0.015) and fat mass (\n                      <jats:italic>P\u00a0<\/jats:italic>\n                      =\n                      <jats:italic>\u00a0<\/jats:italic>\n                      0.007) were also observed, but no patient achieved 7%\u201010% weight loss.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>This study highlights the potential benefits of a 12\u2010week aerobic exercise intervention in improving histological endpoints of MAFLD. The development of strategies to ensure continued engagement in aerobic exercise in MAFLD are needed.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/apt.15989","type":"journal-article","created":{"date-parts":[[2020,7,27]],"date-time":"2020-07-27T14:42:34Z","timestamp":1595860954000},"page":"1387-1398","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":87,"title":["Improvement in histological endpoints of MAFLD following a 12\u2010week aerobic exercise intervention"],"prefix":"10.1111","volume":"52","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8948-1829","authenticated-orcid":false,"given":"Philip","family":"O\u2019Gorman","sequence":"first","affiliation":[{"name":"Discipline of Physiotherapy Trinity College Dublin Dublin Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sara","family":"Naimimohasses","sequence":"additional","affiliation":[{"name":"Department of Hepatology St James\u2019s Hospital Dublin Ireland"},{"name":"Department of Clinical Medicine Trinity College Dublin Dublin Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ann","family":"Monaghan","sequence":"additional","affiliation":[{"name":"Discipline of Physiotherapy Trinity College Dublin Dublin Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Megan","family":"Kennedy","sequence":"additional","affiliation":[{"name":"Discipline of Physiotherapy Trinity College Dublin Dublin Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ashanty M.","family":"Melo","sequence":"additional","affiliation":[{"name":"Department of Immunology Trinity College Dublin Dublin Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Deirdre","family":"N\u00ed Fhloinn","sequence":"additional","affiliation":[{"name":"Department of Hepatology St James\u2019s Hospital Dublin Ireland"},{"name":"Department of Nutritional Sciences University of Surrey Surrey UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Derek G.","family":"Doherty","sequence":"additional","affiliation":[{"name":"Department of Immunology Trinity College Dublin Dublin Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Beddy","sequence":"additional","affiliation":[{"name":"Department of Radiology St James\u2019s Hospital Dublin Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephen P.","family":"Finn","sequence":"additional","affiliation":[{"name":"Department of Histopathology St James\u2019s Hospital and Trinity College Dublin Dublin Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4750-1550","authenticated-orcid":false,"given":"J. 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