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Furthermore, current treatment approaches require long\u2010term exposure of patients to pharmacological agents. There have been significant advances in the understanding of the mechanisms underpinning autoimmunity and an expansion in the available therapeutic agents for suppressing autoimmune responses or potentially restoring self\u2010tolerance.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aim<\/jats:title><jats:p>To review the mechanisms and evidence for experimental therapies that are being actively explored in the management of AIH.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We have reviewed the literature relating to a range of novel therapeutic immunomodulatory treatment strategies and drugs.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Drugs which block B cell\u2010activating factor of the tumour necrosis factor family (BAFF) and tumour necrosis factor \u03b1 are currently in clinical trials for the treatment of AIH. Experimental therapies and technologies to increase immune tolerance, such as pre\u2010implantation factor and regulatory T cell therapies, are undergoing development for application in autoimmune disorders. There is also evidence for targeting inflammatory pathways to control other autoimmune conditions, such as blockade of IL1 and IL6 and Janus\u2010associated kinase (JAK) inhibitors.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>With the range of tools available to clinicians and patients increasing, it is likely that the therapeutic landscape of AIH will change over the coming years and treatment approaches offering lower corticosteroid use and aiming to restore immune self\u2010tolerance should be sought.<\/jats:p><\/jats:sec>","DOI":"10.1111\/apt.16035","type":"journal-article","created":{"date-parts":[[2020,8,15]],"date-time":"2020-08-15T04:50:30Z","timestamp":1597467030000},"page":"1134-1149","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":27,"title":["Review article: experimental therapies in autoimmune 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London UK"},{"name":"The Sheila Sherlock Liver Centre Royal Free Hospital London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ansgar W.","family":"Lohse","sequence":"additional","affiliation":[{"name":"Department of Medicine University Medical Center Hamburg\u2010Eppendorf Hamburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael A.","family":"Heneghan","sequence":"additional","affiliation":[{"name":"Institute of Liver Studies King's College Hospital London 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