{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T06:19:48Z","timestamp":1790489988713,"version":"4.1.0"},"reference-count":25,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2020,8,27]],"date-time":"2020-08-27T00:00:00Z","timestamp":1598486400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100007452","name":"Wu Jieping Medical Foundation","doi-asserted-by":"publisher","award":["320.6750.18012"],"award-info":[{"award-number":["320.6750.18012"]}],"id":[{"id":"10.13039\/100007452","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Aliment Pharmacol Ther"],"published-print":{"date-parts":[[2020,10]]},"abstract":"<jats:title>Summary<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Data on tenofovir alafenamide fumarate (TAF) for preventing mother\u2010to\u2010child transmission of hepatitis B virus (HBV) are lacking.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aims<\/jats:title><jats:p>To investigate the efficacy and safety of TAF therapy for preventing hepatitis B mother\u2010to\u2010child transmission.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Mothers with chronic HBV infection, positive for hepatitis B e\u2010antigen and with HBV DNA &gt;200\u00a0000\u00a0IU\/mL received TAF for preventing mother\u2010to\u2010child transmission were enrolled retrospectively from multiple centres with data collection on mother\u2010infant dyads up to postpartum week 24\u201028. Primary measurements were the mother\u2010to\u2010child transmission rate and infants' malformation rate. Secondary assessments included maternal HBV DNA reduction at delivery, and maternal or infant adverse events during follow up.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Among 71 mothers enrolled, the mean (\u00b1SD) age was 30.3 (\u00b12.2) years. TAF was initiated during the second or third trimester and continued to delivery with a mean (\u00b1SD) duration of 12.8 (\u00b14.0) weeks. At delivery, 85.9% (61\/71) of the mothers achieved HBV DNA &lt;200\u00a0000\u00a0IU\/L. Seventy\u2010three infants (two sets of twins) were born from mothers treated with TAF and none had congenital defects or malformations. All infants received HBV immunoglobulin and vaccine at birth with additional HBV vaccinations at one and six months. At age 24\u201028\u00a0weeks, all infants had negative hepatitis B surface antigen and undetectable levels of HBV DNA (&lt;100\u00a0IU\/mL). Body weight, height, and head circumferences were comparable to national standards for physical development. No severe adverse effects were reported in either mothers or infants.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>TAF for highly viraemic mothers effectively prevented mother\u2010to\u2010child transmission of hepatitis B. There were no safety concerns for either mothers or infants with 24\u201028\u00a0weeks of follow up.<\/jats:p><\/jats:sec>","DOI":"10.1111\/apt.16043","type":"journal-article","created":{"date-parts":[[2020,8,31]],"date-time":"2020-08-31T14:31:02Z","timestamp":1598884262000},"page":"1377-1386","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":45,"title":["Efficacy and safety of tenofovir alafenamide fumarate for preventing mother\u2010to\u2010child transmission of hepatitis B virus: a national cohort study"],"prefix":"10.1111","volume":"52","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7066-2865","authenticated-orcid":false,"given":"Yang","family":"Ding","sequence":"first","affiliation":[{"name":"Shenyang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lihua","family":"Cao","sequence":"additional","affiliation":[{"name":"Qinhuangdao China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liying","family":"Zhu","sequence":"additional","affiliation":[{"name":"Harbin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Huang","sequence":"additional","affiliation":[{"name":"Hunan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chaoshuang","family":"Lin","sequence":"additional","affiliation":[{"name":"Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuming","family":"Wang","sequence":"additional","affiliation":[{"name":"Chong Qing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yingxia","family":"Liu","sequence":"additional","affiliation":[{"name":"Shenzhen China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiuju","family":"Sheng","sequence":"additional","affiliation":[{"name":"Shenyang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shouyun","family":"Wang","sequence":"additional","affiliation":[{"name":"Qinhuangdao China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jian","family":"Fan","sequence":"additional","affiliation":[{"name":"Harbin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruochan","family":"Chen","sequence":"additional","affiliation":[{"name":"Hunan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weiqiang","family":"Gan","sequence":"additional","affiliation":[{"name":"Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bryan","family":"Chen","sequence":"additional","affiliation":[{"name":"Los Angeles CA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3723-6688","authenticated-orcid":false,"given":"Calvin Q.","family":"Pan","sequence":"additional","affiliation":[{"name":"Beijing China"},{"name":"New York NY USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,8,27]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2468-1253(18)30056-6"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1098\/rstb.2016.0274"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.7150\/ijms.2.36"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.7156\/v2i3p111"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2017.03.021"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/apt.14577"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2011.10.041"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.15585\/mmwr.rr6701a1"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2893.2011.01492.x"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.28302"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/cld.728"},{"key":"e_1_2_8_13_1","unstructured":"APR.Antiviral Pregnancy Registry Interim report \u2010 January 1989 through July 2019; Issued in December2019.http:\/\/wwwapregistrycom. 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