{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T02:32:25Z","timestamp":1778639545792,"version":"3.51.4"},"reference-count":36,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2020,9,4]],"date-time":"2020-09-04T00:00:00Z","timestamp":1599177600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100007028","name":"Leona M. and Harry B. Helmsley Charitable Trust","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007028","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004587","name":"Instituto de Salud Carlos III","doi-asserted-by":"publisher","award":["PI16\/00721"],"award-info":[{"award-number":["PI16\/00721"]}],"id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Aliment Pharmacol Ther"],"published-print":{"date-parts":[[2020,11]]},"abstract":"<jats:title>Summary<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Identifying predictors of therapeutic response is the cornerstone of personalised medicine.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aim<\/jats:title><jats:p>To identify predictors of long\u2010term healing of severe inflammatory lesions based on magnetic resonance enterography (MRE) findings in patients with Crohn\u2019s disease (CD) treated with tumour necrosis factor alpha (TNF\u2010\u03b1) inhibitors.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This prospective longitudinal single\u2010centre study included patients with clinically active CD requiring treatment with TNF\u2010\u03b1 inhibitors with at least one intestinal segment with a severe inflammatory lesion detected by MRE (segmental MaRIA \u226511). MRE data were obtained at baseline, and at weeks 14 and 46. The primary endpoint was healing of severe inflammatory lesions (MaRIA &lt;11) in each segment. The secondary endpoint was healing of all severe inflammatory lesions on a per\u2010patient analysis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>We included 58 patients with 86 intestinal segments with severe inflammatory lesions. At week 46, healing of severe lesions was found in 51\/86 (59.3%) segments, and complete healing of inflammatory lesions in all segments was found in 28\/58 (48.6%) patients. Multivariable analysis found baseline\u2010negative predictors of long\u2010term healing of severe inflammation were ileal (as opposed to colonic) location (OR 0.00, [0.00\u20100.56] <jats:italic>P<\/jats:italic>\u00a0=\u00a00.002) and presence of creeping fat on MRE (OR 0.00 [0.00\u20100.57]; <jats:italic>P<\/jats:italic>\u00a0=\u00a00.001). Persistence of segmental MaRIA score &gt;10.6 at week 14 was a negative predictor of healing at week 46 (OR 0.3 [0.04\u2010\u20100.38]; <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.001).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>In patients with CD, the absence of creeping fat detected at baseline MRE and location of severe inflammatory lesions are clinically relevant predictors of long\u2010term healing of severe inflammation under treatment with TNF\u2010\u03b1 inhibitors.<\/jats:p><\/jats:sec>","DOI":"10.1111\/apt.16069","type":"journal-article","created":{"date-parts":[[2020,9,9]],"date-time":"2020-09-09T08:01:50Z","timestamp":1599638510000},"page":"1563-1573","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":40,"title":["Pre\u2010treatment magnetic resonance enterography findings predict the response to TNF\u2010alpha inhibitors in Crohn's disease"],"prefix":"10.1111","volume":"52","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1814-4198","authenticated-orcid":false,"given":"Jordi","family":"Rimola","sequence":"first","affiliation":[{"name":"Radiology Department IBD Unit Hospital Cl\u00ednic de Barcelona Barcelona Spain"},{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red Enfermedades Hep\u00e1ticas y Digestivas (CIBERehd) Barcelona Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Agn\u00e8s","family":"Fern\u00e0ndez\u2010Clotet","sequence":"additional","affiliation":[{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red Enfermedades Hep\u00e1ticas y Digestivas (CIBERehd) Barcelona Spain"},{"name":"Gastroenterology Department IBD Unit Hospital Cl\u00ednic de Barcelona Barcelona Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nunzia","family":"Capozzi","sequence":"additional","affiliation":[{"name":"Radiology Department IBD Unit Hospital Cl\u00ednic de Barcelona Barcelona Spain"},{"name":"Radiology Department Policlinico Universitario Sant\u2019Orsola\u2010Malpighi Bologna Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S\u00f2nia","family":"Rojas\u2010Farreras","sequence":"additional","affiliation":[{"name":"Statistician Freelance Barcelona Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ignacio","family":"Alfaro","sequence":"additional","affiliation":[{"name":"Gastroenterology Department IBD Unit Hospital Cl\u00ednic de Barcelona Barcelona Spain"},{"name":"Gastroenterology Department Hospital regional de Concepci\u00f3n Concepcion Chile"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sonia","family":"Rodr\u00edguez","sequence":"additional","affiliation":[{"name":"Radiology Department IBD Unit Hospital Cl\u00ednic de Barcelona Barcelona 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