{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T20:21:02Z","timestamp":1790367662868,"version":"4.1.0"},"reference-count":47,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2020,9,15]],"date-time":"2020-09-15T00:00:00Z","timestamp":1600128000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Aliment Pharmacol Ther"],"published-print":{"date-parts":[[2020,11]]},"abstract":"<jats:title>Summary<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Body composition may be modified after improvement of portal hypertension (PHT) by transjugular intrahepatic portosystemic shunt (TIPSS) insertion.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aims<\/jats:title><jats:p>To evaluate changes in body composition following TIPSS placement, their relationship with radiological TIPSS patency and function, and the predictive value of these parameters<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We retrospectively included 179 patients with cirrhosis who underwent TIPSS placement in our centre for severe PHT from 2011 to 2017. CT scan\u2010based surveillance was performed at baseline, 1\u20103 (M1\u2010M3) and 6\u00a0months (M6).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The median model for end\u2010stage liver disease (MELD) score was 11.4 (8.8\u201015.1) and Child\u2010Pugh score 8 (7\u20109). Only the MELD score (HR 1.14, 95% CI 1.08\u20101.20) and sarcopenia assessed by transversal right psoas muscle thickness at the umbilical level\/height (TPMPT\/height) (HR 0.86, 95% CI 0.79\u20100.96) were independently associated with 6\u2010month mortality on multivariate analysis. After TIPSS insertion, TPMT\/height increased from 19\u00a0mm\/m (baseline) to 19.6\u00a0mm\/m (M1\u2010M3, <jats:italic>P<\/jats:italic>\u00a0=\u00a00.004) and 21.1\u00a0mm\/m (M6, <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.0001). The improvement and its extent were dependent on the radiological patency and dysfunction of TIPSS. Subcutaneous fat surface (SCFS) increased from 183.4 to 193\u00a0cm<jats:sup>2<\/jats:sup> (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.0001) and 229.8\u00a0cm<jats:sup>2<\/jats:sup> (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.0001), respectively. We observed a decrease in visceral fat surface (VFS) between baseline and M1\u2010M3 (163.5\u2010140.5\u00a0cm<jats:sup>2<\/jats:sup> [<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.0001]), but not between M1\u2010M3 and M6 (140.5\u2010141.2\u00a0cm<jats:sup>2<\/jats:sup> [<jats:italic>P<\/jats:italic>\u00a0=\u00a00.9]). SCFS and VFS did not seem to be modified by radiological TIPSS patency and dysfunction.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Sarcopenia is independently associated with 6\u2010month outcome and improves after TIPSS placement, together with an inverse evolution of subcutaneous and visceral fat. TIPSS not only treats PHT but also improves body composition.<\/jats:p><\/jats:sec>","DOI":"10.1111\/apt.16080","type":"journal-article","created":{"date-parts":[[2023,9,5]],"date-time":"2023-09-05T09:16:45Z","timestamp":1693905405000},"page":"1516-1526","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":48,"title":["Consequences of TIPSS placement on the body composition of patients with cirrhosis and severe portal hypertension: a large retrospective CT\u2010based surveillance"],"prefix":"10.1111","volume":"52","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2220-6646","authenticated-orcid":false,"given":"Florent","family":"Artru","sequence":"first","affiliation":[{"name":"Service des maladies de l'appareil digestif H\u00f4pital Claude Huriez CHU Lille Lille France"},{"name":"U995 \u2010 LIRIC \u2013 Lille Inflammation Research Center Universit\u00e9 de Lille\/Inserm\/CHU de Lille Lille France"},{"name":"Service de 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