{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,30]],"date-time":"2026-01-30T00:22:44Z","timestamp":1769732564481,"version":"3.49.0"},"reference-count":25,"publisher":"Wiley","issue":"11-12","license":[{"start":{"date-parts":[[2020,9,20]],"date-time":"2020-09-20T00:00:00Z","timestamp":1600560000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Aliment Pharmacol Ther"],"published-print":{"date-parts":[[2020,12]]},"abstract":"<jats:title>Summary<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Fibroscan\u2010derived liver stiffness decreases after anti\u2010viral treatment for hepatitis C virus (HCV) infection, which may affect the associations and interpretation of liver stiffness.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aims<\/jats:title><jats:p>To assess whether liver stiffness pre\u2010 or post\u2010anti\u2010viral therapy is associated with the development of decompensated cirrhosis, hepatocellular carcinoma (HCC) or death.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>In this retrospective cohort study, we identified US veterans who initiated HCV treatment and had at least one liver stiffness before (n\u00a0=\u00a0492) or after (n\u00a0=\u00a0877) HCV therapy. We used Cox proportional hazards regression (adjusting for age, race\/ethnicity, history of cirrhosis, body mass index, diabetes, FIB\u20104 score, Charlson comorbidity index, alcohol use disorder, Model for end\u2010stage liver disease score and sustained virological response status) to determine the associations between pre\u2010 or post\u2010treatment liver stiffness values and the development of decompensated cirrhosis, HCC, death or liver transplant.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In the post\u2010treatment liver stiffness cohort, during a mean follow\u2010up of 27.3\u00a0months, 21 (2.4%) developed decompensated cirrhosis, 26 (3.0%) developed HCC and 57 (6.5%) died or underwent liver transplant. Compared to patients with post\u2010treatment liver stiffness \u226412.5\u00a0kPa, those with post\u2010treatment liver stiffness &gt;20\u00a0kPa, had higher rates of developing decompensated cirrhosis (adjusted HR 3.85, 95% CI 1.29\u201011.50) and the composite outcome of death, liver transplant, decompensated cirrhosis or HCC (adjusted HR 1.95, 95% CI: 1.07\u20103.56). There were no significant associations between pre\u2010treatment liver stiffness and any outcomes on multivariable analysis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Post\u2010treatment liver stiffness &gt;20\u00a0kPa, but not pre\u2010treatment liver stiffness, was independently associated with the development of decompensated cirrhosis and the composite outcome in multivariable analyses. Measuring liver stiffness should be considered after anti\u2010viral treatment because it predicts adverse outcomes even beyond routinely available clinical predictors.<\/jats:p><\/jats:sec>","DOI":"10.1111\/apt.16092","type":"journal-article","created":{"date-parts":[[2023,9,4]],"date-time":"2023-09-04T06:37:57Z","timestamp":1693809477000},"page":"1717-1727","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Fibroscan liver stiffness after anti\u2010viral treatment for hepatitis C is independently associated with adverse outcomes"],"prefix":"10.1111","volume":"52","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4196-6077","authenticated-orcid":false,"given":"Philip","family":"Vutien","sequence":"first","affiliation":[{"name":"Division of Gastroenterology and Hepatology University of Washington Seattle WA USA"},{"name":"Department of Medicine Veterans Affairs Puget Sound Healthcare System and University of Washington Seattle WA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2348-0580","authenticated-orcid":false,"given":"Nicole J.","family":"Kim","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Hepatology University of Washington Seattle WA USA"},{"name":"Department of Medicine Veterans Affairs Puget Sound Healthcare System and University of Washington Seattle WA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7163-2062","authenticated-orcid":false,"given":"Andrew M.","family":"Moon","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Hepatology University of North Carolina Chapel Hill NC USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Meredith","family":"Pearson","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Hepatology University of Washington Seattle WA USA"},{"name":"Department of Medicine Veterans Affairs Puget Sound Healthcare System and University of Washington Seattle WA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Feng","family":"Su","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Hepatology University of Washington Seattle WA USA"},{"name":"Department of Medicine Veterans Affairs Puget Sound Healthcare System and University of Washington Seattle WA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kristin","family":"Berry","sequence":"additional","affiliation":[{"name":"Health Services Research and Development Veterans Affairs Puget Sound Healthcare System Seattle WA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hannah","family":"Gelman","sequence":"additional","affiliation":[{"name":"Health Services Research and Development Veterans Affairs Puget Sound Healthcare System Seattle WA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1796-8977","authenticated-orcid":false,"given":"George N.","family":"Ioannou","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Hepatology University of Washington Seattle WA USA"},{"name":"Department of Medicine Veterans Affairs Puget Sound Healthcare System and University of Washington Seattle WA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2020,9,20]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1136\/gut.2005.069153"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.21665"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2036.2008.03825.x"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.5009\/gnl150211"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.dld.2018.02.010"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10620-019-05604-8"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/liv.13179"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1097\/MCG.0b013e318050074f"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/jgh.12401"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1746.2009.06194.x"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/apt.13722"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2017.04.038"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2019.07.033"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2018.07.024"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2017.03.017"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.28906"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/0021-9681(87)90171-8"},{"key":"e_1_2_8_19_1","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0204412","article-title":"Differences in hepatocellular carcinoma risk, predictors and trends over time according to etiology of cirrhosis","volume":"13","author":"Ioannou GN","year":"2018","journal-title":"PLoS One"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2017.06.012"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.22870"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2017.07.016"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.30885"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2013.10.027"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2011.07.005"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2011.01.051"}],"container-title":["Alimentary Pharmacology &amp; Therapeutics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/apt.16092","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,4]],"date-time":"2023-09-04T06:38:26Z","timestamp":1693809506000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/apt.16092"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,9,20]]},"references-count":25,"journal-issue":{"issue":"11-12","published-print":{"date-parts":[[2020,12]]}},"alternative-id":["10.1111\/apt.16092"],"URL":"https:\/\/doi.org\/10.1111\/apt.16092","archive":["Portico"],"relation":{},"ISSN":["0269-2813","1365-2036"],"issn-type":[{"value":"0269-2813","type":"print"},{"value":"1365-2036","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,9,20]]},"assertion":[{"value":"2020-02-24","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-08-31","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-09-20","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}