{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T16:58:07Z","timestamp":1790787487189,"version":"4.1.0"},"reference-count":31,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2020,12,12]],"date-time":"2020-12-12T00:00:00Z","timestamp":1607731200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Aliment Pharmacol Ther"],"published-print":{"date-parts":[[2021,2]]},"abstract":"<jats:title>Summary<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Anti\u2010tumour necrosis factor (anti\u2010TNF) therapy increases the risk of tuberculosis (TB). Given limitations of screening techniques, it remains uncertain if patients receiving anti\u2010TNF in TB endemic regions should be screened for latent infection with chemoprophylaxis restricted to those with proven infection, or if all patients should receive chemoprophylaxis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aims<\/jats:title><jats:p>To compare the incidence of active TB with infliximab (IFX) following targeted and universal TB chemoprophylaxis, and to determine the rates of adverse events (AE) related to TB chemoprophylaxis<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A multi\u2010centre retrospective cohort study was performed at 18 hospitals in China of 1968 adult patients with IBD receiving IFX from 2009 to 2017. TB screening prior to IFX was performed with chest X\u2010ray and\/or computed tomography [CT] and immune reactivity testing (interferon\u2010\u03b3 release assay and\/or tuberculin skin test). Patients were followed\u2010up for a minimum of 3\u00a0months after IFX discontinuation, or until last hospital visit if IFX therapy was ongoing. Targeted strategy was defined as TB chemoprophylaxis only for patients with a positive latent TB screen, with universal strategy defined as TB chemoprophylaxis for all patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Mean follow\u2010up was 1.07\u00a0\u00b1\u00a00.87\u00a0years with a total follow\u2010up of 2102 patient\u2010years. There were 1433 patients in the targeted and 483 patients in the universal TB chemoprophylaxis groups, with no significant difference in the incidence rates of active TB between groups (673.3 per 100\u00a0000 population per year vs 891.5 per 100\u00a0000 population per year, <jats:italic>P<\/jats:italic>\u00a0=\u00a00.60). In the targeted group, 55\/1433 patients received TB chemoprophylaxis compared with 483\/483 in the universal group, with significantly fewer AEs related to TB chemoprophylaxis in the targeted compared to the universal group (0.35% (5\/1433) vs 6.8% (33\/483), <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.05).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>In this study of patients receiving IFX in a TB endemic area, universal chemoprophylaxis was not associated with a reduced risk of active TB when compared to a targeted chemoprophylaxis strategy, and AEs were more common. This supports the use of targeted TB chemoprophylaxis when anti\u2010TNF therapy is initiated in TB endemic regions.<\/jats:p><\/jats:sec>","DOI":"10.1111\/apt.16130","type":"journal-article","created":{"date-parts":[[2023,9,3]],"date-time":"2023-09-03T18:17:16Z","timestamp":1693765036000},"page":"390-399","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Targeted versus universal tuberculosis chemoprophylaxis in 1968 patients with inflammatory bowel disease receiving anti\u2010TNF therapy in a tuberculosis endemic region"],"prefix":"10.1111","volume":"53","author":[{"given":"Lingna","family":"Ye","sequence":"first","affiliation":[{"name":"Department of Gastroenterology Xiasha Branch of Sir Run Run Shaw Hospital College of Medicine Zhejiang University Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5298-4780","authenticated-orcid":false,"given":"Thomas P.","family":"Chapman","sequence":"additional","affiliation":[{"name":"Translational Gastroenterology Unit NIHR Oxford Biomedical Research Centre Oxford University Hospitals NHS Foundation Trust John Radcliffe Hospital Oxford UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhenzhen","family":"Wen","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Sir Run Run Shaw Hospital College of Medicine Zhejiang University Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lang","family":"Lin","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology The Sixth Affiliated Hospital of Sun Yat\u2010sen University Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yun","family":"Qiu","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology The First Affiliated Hospital of Sun Yat\u2010sen University Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhanju","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology The Shanghai Tenth People's Hospital Tongji University Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhihua","family":"Ran","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Hepatology Key Laboratory of Gastroenterology and Hepatology Ministry of Health Shanghai Inflammatory Bowel Disease Research Center Renji Hospital School of Medicine Shanghai Jiao Tong University Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiaming","family":"Qian","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Peking Union Medical College Hospital Chinese Academy Medical Sciences and Peking Union Medical College Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kaichun","family":"Wu","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Cancer Biology National Clinical Research Center for Digestive Diseases and Xijing Hospital of Digestive Diseases Fourth Military Medical University Xi'an China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiang","family":"Gao","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology The Sixth Affiliated Hospital of Sun Yat\u2010sen University Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pinjin","family":"Hu","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology The Sixth Affiliated Hospital of Sun Yat\u2010sen University Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Minhu","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology The First Affiliated Hospital of Sun Yat\u2010sen University Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simon P. L.","family":"Travis","sequence":"additional","affiliation":[{"name":"Translational Gastroenterology Unit NIHR Oxford Biomedical Research Centre Oxford University Hospitals NHS Foundation Trust John Radcliffe Hospital Oxford UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qian","family":"Cao","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Sir Run Run Shaw Hospital College of Medicine Zhejiang University Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"The Chinese IBD Elite Union","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,12,12]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2011-300613"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1517\/14712598.2014.858695"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2249.2010.04146.x"},{"key":"e_1_2_9_5_1","unstructured":"World Health Organization.Global tuberculosis report 2019.https:\/\/www.who.int\/tb\/publications\/global_report\/en\/. 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